复方远志合剂对急性支气管炎疗效及安全性评价.docVIP

复方远志合剂对急性支气管炎疗效及安全性评价 　　[摘要] 目的:观察应用复方远志合剂对急性支气管炎的疗效及安全性。方法:将100例急性支气管炎患者随机分为治疗组(50例)和对照组(50例),治疗组在支气管炎常规治疗基础上给予口服复方远志合剂治疗,疗程为1周,于治疗前后分别测定末梢血白细胞计数(WBC)及分类,部分患者做X线检查。结果:治疗组临床痊愈率和总有效率分别为80.0%和98.0%;对照组临床痊愈率和总有效率分别为60.0%和92.0%;治疗组治疗后临床痊愈率及总有效率明显优于对照组(P0.05)。结论:复方远志合剂对急性支气管炎有明显的镇咳祛痰效果,安全性良好。 　　[关键词] 复方远志合剂;中药治疗;疗效评价 　　[中图分类号] R562.2+1[文献标识码] A[文章编号] 1673-7210(2010)02(b)-016-03 　　 　　The efficacy and safety of Fufangyuanzhi Mixture for acute bronchitis 　　SUN Yi, CHU Fuming, CHENG Shenling, GUO Ling, HUANG Zhen 　　(Department of Pharmacy, Tengzhou Central Peoples Hospital of Shandong Province, Tengzhou 277500, China) 　　[Abstract] Objective: To observe the efficacy and safety of Fufangyuanzhi Mixture for acute bronchitis. Methods: 100 patients with acute bronchitis were randomly divided into treatment group (n=50) and control group (n=50). In addition to the usual treatment, the Fufangyuanzhi Mixture was given to the treatment group for a course of one week. White blood cell count and its categorization of the peripheral blood were taken before and after treatment. X-ray examination was taken on some cases. Results: The clinical cure rate and total effective rate of treatment group were 80.0% and 98.0% respectively. The clinical cure rate and total effective rate of control group were 60.0% and 92.0% respectively. The clinical cure rate and total effective rate of treatment group were significantly higher than those of control group (P0.05). Conclusion: The mixture is markedly effective and safe for cough and phlegm of acute bronchitis. 　　[Key words] Fufangyuanzhi Mixture; Treatment by Chinese herbs; Therapeutic evaluation 　　 　　急性上呼吸道感染是指鼻到下级支气管树(不包括肺泡)气道黏膜的炎症。该病是临床常见多发病,咳嗽、咳痰为其主要症状,是美国发病率最高的急性病之一[1]。中医中药在止咳、化痰、退热等方面具有明显的优势。中医认为肺为娇脏,位居华盖,喜润恶燥,易受外邪侵袭;在生理上,“肺主气,司呼吸,其有宣发和肃降的作用”[2];而咳嗽、咳痰多因邪热由口鼻而入,壅肺,肺气不宣失其肃降之职,致肺气上逆,故治疗宜清肺热、调肃降、止咳化痰为主。我院在镇咳祛痰治疗中积累了丰富的临床经验,如急支糖浆、复方鲜竹沥口服液、肺力咳合剂、远志合剂等,均收到了良好的效果,在此基础上,我院又研制出了复方远志合剂,这一院内制剂在临床上应用近20年来,使用量达12万瓶,疗效确切,质优价廉,无不良反应报道,收到了很好的经济效益