复方甘草酸苷与阿维A胶囊联合治疗银屑病疗效和安全性研究.docVIP

复方甘草酸苷与阿维A胶囊联合治疗银屑病疗效和安全性研究 　　[摘要] 目的 对复方甘草酸苷与阿维A胶囊联合治疗银屑病的疗效和安全性进行研究及判定。 方法 方便选取该院2015年2月―2016年1月收治的60例银屑病患者，随机分组为对照组与观察组，各30例，对照组给予患者阿维A胶囊进行治疗，观察组给予患者复方甘草酸苷与阿维A胶囊联合治疗，并观察2组银屑病患者的临床疗效，银屑病严重程度指数及不良反应发生率。 结果 银屑病患者的总好转率为96.67%，银屑病严重程度指数为（2.05±2.13）分，均优于对照组，且不良反应发生率为20.00%，低于对照组（P0.05）。 结论 复方甘草酸苷与阿维A胶囊联合治疗银屑病可提高其临床疗效，降低严重程度，且不良反应较少，患者均可耐受，其效果显著，值得在临床中推广实施。 　　[关键词] 阿维A胶囊；复方甘草酸苷；临床疗效；不良反应 　　[中图分类号] R758.63 [文献标识码] A [文章编号] 1674-0742（2017）01（a）-0008-03 　　[Abstract] Objective To compound glycyrrhizin and Avi A capsule combined treatment of psoriasis efficacy and safety studies and determination. Methods Convenient selection the hospital will be from February 2015 to January 2016 were treated 60 cases of psoriasis patients were randomized to the control group and the observation group， the two groups of patients with psoriasis， 30 patients in the control group were given patients Avi A capsules treatment， observation group of patients with compound glycyrrhizin Avi a capsule combination therapy， and to observe the clinical efficacy of the two groups of patients with psoriasis， psoriasis severity index and incidence of adverse reactions. Results The overall psoriasis improvement was 96.67%， psoriasis severity index（2.05±2.13） scores were better than the control group， and the adverse reaction rate was 13.33%， lower than the control group. Conclusion Compound glycyrrhizin and Avi A capsule combined treatment of psoriasis can improve its clinical efficacy， reduce the severity and fewer adverse reactions tolerated by all patients， the effect is significant， it is worth to promote the implementation in the clinic. 　　[Key words] Avi A capsule； Compound glycyrrhizin； Clinical efficacy； Adverse reactions 　　?y屑病为慢性炎症性皮肤疾病，又称牛皮藓，具有病程长、易复发等特征，临床中较难治愈，青壮年为银屑病的主要发病人群，对其身心健康造成极大的负面影响，银屑病以鳞屑、红斑为主要临床特征，全身均有概率发病，其四肢、头皮较为多见，冬季发病概率较高。相关研究表明，遗传因素与银屑病的发病具有密切关联，其具有HLA抗原患者的发病率较高[1]；有学者认为[2-3]，皮损T细胞、外周血、抗链球菌组及细胞培养等方面均可证实银屑病的发病与链球菌感染相关，其金黄色葡萄球菌加重皮损，其因素与金黄色葡萄球菌外毒素超抗原相关；其炎症细胞及因子侵入机体，精神紧张，药物因素及