复方甘草酸苷注射液与前列地尔联合治疗急性黄疸型肝炎临床效果研究.docVIP

复方甘草酸苷注射液与前列地尔联合治疗急性黄疸型肝炎临床效果研究 　　[摘要] 目的 探讨复方甘草酸苷注射液联合前列地尔治疗急性黄疸型肝炎的效果。 方法 收集的76例患者均为2014年3月～2015年10月来我院治疗的黄疸型肝炎病例，随机分为两组，每组各38例，对照组用门冬氨酸钾镁注射液与苦黄注射液治疗，观察组使用复方甘草酸苷注射液与前列地尔联合治疗，1个疗程为4周。比较分析两组的临床疗效及治疗前后TBIL、AST、ALT水平。 结果 观察组治疗后的总有效率为92.11%，显著高于对照组的73.68%，差异有统计学意义（P0.05）。两组治疗后组内比较：对照组和观察组TBIL、AST、ALT与治疗前比较明显降低，差异有统计学意义（P0.05）。两组治疗后组间比较：观察组TBIL、AST、ALT明显低于对照组，差异有统计学意义（P0.05）。 结论 复方甘草酸苷注射液与前列地尔联合治疗急性黄疸型肝炎效果较好，可提高临床治疗总有效率，缓解临床症状，改善肝功能，值得临床推广应用。 　　[关键词] 急性黄疸型肝炎；复方甘草酸苷；前列地尔；静脉滴注 　　[中图分类号] R512 [文献标识码] B [文章编号] 1673-9701（2017）13-0102-03 　　[Abstract] Objective To discuss the effect of compound glycyrrhizin injection combined with alprostadil in treatment of acute icteric hepatitis. Methods 76 patients with icteric hepatitis treated in our hospital from March 2014 to October 2015 were selected and randomly divided into two groups， each with 38 cases. Patients in the control group were given potassium magnesium aspartate injection and Kuhuang injection， while patients in the observation group were treated by compound glycyrrhizin injection combined with alprostadil， both for a treatment course of 4 weeks. The clinical effects and TBIL， AST， and ALT levels before and after treatment were compared between two groups. Results The overall response rate of the observation group was 92.11%， significantly higher than the 73.68% in the control group， the difference was significant（P0.05）. As to intragroup comparison， after treatment， the TBIL， AST， and ALT levels were significantly lower than those before treatment in both groups， the difference was significant（P0.05）. As to intergroup comparison， the TBIL， AST， and ALT levels in the observation group after treatment were significantly lower than in the control group， the difference was significant（P0.05）. Conclusion Compound glycyrrhizin injection combined with alprostadil have good effect in treatment of acute icteric hepatitis， which can improve the overall response rate， relieve clinical symptoms， and improve liver function， t