妊娠期高血压疾病患者血清同型半胱氨酸和超敏C反应蛋白检测临床意义.docVIP

妊娠期高血压疾病患者血清同型半胱氨酸和超敏C反应蛋白检测临床意义 　　【摘要】 目的 探?妊娠期高血压疾病（HDCP）患者血清同型半胱氨酸（Hcy）和超敏C反应蛋白（hs-CRP）联合检测的临床价值。方法 135例HDCP患者作为观察组， 其中， 妊娠期高血压66例（妊娠期高血压组）， 轻度子痫前期38例（轻度子痫前期组）， 重度子痫前期31例（重度子痫前期组）；同期行产前检查的33例正常孕妇作为对照组。分别采血检测各组血清Hcy和hs-CRP水平并进行比较分析。结果 观察组血清Hcy（16.73±5.76）μmol/L和hs-CRP（12.47±4.28）mg/L均高于对照组（6.13±1.87）μmol/L、（3.29±0.82）mg/L， 差异均具有统计学意义（P轻度子痫前期组妊娠期高血压组， P0.01）。直线相关分析显示， HDCP患者血清Hcy与hs-CRP水平呈正相关（r=0.379， P0.05）。结论 血清Hcy和hs-CRP均为反映HDCP患者病情严重程度的敏感指标， 联合检测两者水平对判断HDCP患者的病情有一定的临床价值。 　　【关键词】 妊娠期高血压疾病；同型半胱氨酸；超敏C反应蛋白 　　DOI：10.14163/j.cnki.11-5547/r.2017.03.001 　　Clinical significance of serum homocysteine and high-sensitivity c-reactive protein in detection of patients with hypertensive disorder complicating pregnancy YANG Ping， HE Xia， LIN Li-hong. Department of Gynaecology and Obstetrics， Guangzhou City Baiyun District Hospital of Traditional Chinese Medicine， Guangzhou 510470， China 　　【Abstract】 Objective To explore the clinical value of combined detection of serum homocysteine （Hcy） and high-sensitivity c-reactive protein （hs-CRP） in patients with hypertensive disorder complicating pregnancy （HDCP）. Methods There were 135 HDCP patients as observation group， including 66 gestational hypertension cases （gestational hypertension group）， 38 mild preeclampsia cases （mild preeclampsia group）， 31 severe preeclampsia cases （severe preeclampsia group）. Concurrent 33 normal pregnant women for antenatal examination as control group. Serum Hcy and hs-CRP level were detected by blood test in all groups for comparative analysis. Results The observation group had serum Hcy as （16.73±5.76） μmol/L， and hs-CRP as （12.47±4.28） mg/L， 　　which were all higher than （6.13±1.87） μmol/L and （3.29±0.82） mg/L in the control group， and their difference had statistical significance （Pmild preeclampsia groupgestational hypertension group， P 　　【Key words】 Hypertensive disorder complicating pregnancy； Homocysteine； High-sensitivity c-reactive protein 　　妊娠期高血压疾病（hypertensive disorder complicating