妊娠期甲状腺功能减退症对妊娠结局影响.docVIP

妊娠期甲状腺功能减退症对妊娠结局影响 　　[摘要] 目的 探讨妊娠期甲状腺功能减退症对妊娠结局的影响。 方法 对2013年6月1日～2014年5月31日期间在连云港市妇幼保健医院产科门诊产检6962例孕妇进行甲状腺功能筛查，选择患妊娠期甲状腺功能减退症的282例孕妇作为试验组，试验组予药物治疗，随机选择甲状腺功能正常的孕妇共300例作为正常对照组，观察两组孕妇的妊娠结局。 结果 早孕期治疗组自然流产发生率高于正常对照组（P0.05）；中晚孕期治疗组妊娠期高血压疾病、早产发生率高于对照组及早孕期接受治疗组（P0.05）；未治疗组研究对象早产、胎盘早剥及胎儿生长受限（FGR）的发生率高于对照组及早孕期治疗组（P0.05）。 结论 妊娠期甲减对妊娠及其结局有许多负面影响，会增加自然流产、早产、FGR、妊娠期高血压疾病的发生率；通过及时、适当的治疗，可降低不良妊娠的发生率。 　　[关键词] 妊娠期；甲减；TSH；妊娠结局 　　[中图分类号] R714.2 [文献标识码] B [文章编号] 1673-9701（2016）20-0044-04 　　[Abstract] Objective To discuss the gestational hypothyroidism on pregnancy outcome. Methods Thyroid function screening was taken for 6962 pregnant women who were served with prenatal care in Lianyungang Maternal and Child Health Hospital from 2013 June 1 to 2014 May 31. 282 women with hypothyroidism during pregnancy were found， who treated with drugs were selected as treatment group 300 normal thyroid function women were randomly selected as control group. The pregnancy outcome was recorded in two groups. Results The incidence of spontaneous abortion in early pregnancy treated group was higher than that in control group， with statistically significant difference（P0.05）. The incidence of gestational hypertension， premature birth in late pregnancy treated group were higher than that in control group and early pregnancy treated group， with statistically significant difference（P0.05）. The incidence of preterm delivery， placental abruption and fetal growth restriction in untreated group were all higher than those in control group and early pregnancy treated group， with statistically significant difference（P0.05）. Conclusion The gestational hypothyroidism has negatively affect on the pregnancy and its outcome， and can increase the incidence of spontaneous abortion， premature birth， FGR， and gestational hypertension. Timely and appropriate treatment can reduce the incidence of adverse pregnancy. 　　[Key words] Pregnancy； Hypothyroidism； TSH； Pregnancy outcomes 　　甲状腺功能减退症（以下简称甲减）是由于甲状腺激素合成及分泌减少，或者其生理效