Tempol在调节肥胖相关性高血压大鼠肾脏RAS系统平衡中的作用研究-内科学(心血管病)专业论文.docxVIP

第三军 第三军医大学硕士学位论文 万方数据 万方数据 Role of Tempol in the regulation of renal RAS components of obese-related hypertensive rats Abstract Background： Cardiovascular disease is an important and serious disease affecting human health. Currently in cardiovascular disease, the incidence of hypertension shows an increasing trend. Obesity is a major risk factor of hypertension, and obesity-related hypertension attracts more and more peoples attention. So it has an important clinical significance to prevent and treat by elucidating the mechanism of obesity-related hypertension. In the regulation of blood pressure, in addition to the blood vessels, heart and brain, the kidney also plays a very important role in it. The kidney is a vital organ for urinary sodium excretion to regulate blood pressure. Renin-angiotensin-aldosterone system plays an important role in the regulation of blood pressure. RAS is including a classical pathway (renin-angiotensinⅡ-angiotensin receptor type Ⅰ) and a non-classical pathway [renin - angiotensin Ⅱ- angiotensin receptor type Ⅱand renin -Ang (1-7) -Mas receptor], which maintain a stable blood pressure by mutual adjustment. ANG II is a major RAS peptide that induces its effects by binding to two major receptor subtypes, AT1R and AT2R. AT1Rs are ubiquitously expressed and are involved in mediating vasoconstriction, antinatriuresis, contributed to an increase in blood Pressure, whereas activation of AT2Rs are associated with vasodilatation, apoptosis, antiproliferation, and natriuresis, potentially lower blood pressure, therefore, considered as functional antagonists to the AT1Rs. Besides, the activation of the “nonclassic pathway” (ACE2/Ang-(1-7)/Mas) opposes AT1 mediated effects, leading to vasodilation and enhance pressure natriuresis. In obesity-related hypertension, the classical pathway and non-classical pathway in renal RAS are often unbalanced, leading to an impair in natriuresis and diuresis , which causes an increase in blood pressure. Although