TLR4信号传导对急性胰腺炎大鼠中性粒细胞凋亡调控的意义-肝胆外科专业论文.docxVIP

汕头大 汕头大学医学院临床型硕士学位论文 PAGE PAGE IV the inflammatory response exinsts in acute pancreatitis；There was a remarkably negative correlation between the serum IL-8 and PMN apoptosis rate.Therefore， it may be the cause of the decrease or delays in the neutrophils apoptosis that led to excessive inflammation and tissue damage in body；In acute pancreatitis， especially when the ANP，PMN apoptosis was delayed， which sustained release of inflammatory mediators, and high expression of TLR4 in neutrophils, which may be involved in the regulation of neutrophil apoptosis delay. Keyword:cute pancreatitis;apoptosis;Toll-likereceptor 4；polymorphonuclear neutrophil. 英 文 缩 略 词 缩略词 英文名称 中文名称 ANP acute necrotizing pancreatitis 急性坏死性胰腺炎 AEP acute edematous pancreatitis 急性水肿型胰腺炎 AP Acute pancreatitis 急性胰腺炎 LRR leucine-rich repeat 富含氨基酸的重复序列 IRAK IL-1 receptor-associated kinase IL-1 受体相关的激酶 IL-8 interleukin-8 白介素 8 IкB inhibitor кB 抑制因子кB INF-β interferon β β干扰素 IRF3 interferon regulatory factor 干扰素调节因子 3 IKK IκB kinase IκB 激酶复合体 MyD88 myeloid differentiation protein88 髓质分化蛋白 88 MOF Multiple Organ failure HYPERLINK /view/1398047.htm 多器官功能衰竭 MODS Multiple Organ Dysfunction Syndrome 多器官功能障碍综合征 MAPK mitogen-activated protein kinases 丝裂原活化蛋白 OD optical density 光密度 PI propidine iodide 碘化丙啶 PMN polymorphonuclear neutrophils 中性粒细胞 ROS reactive oxygen species 活性氧 RBC Red blood cells 红细胞 SAP Severe acute pancreatitis 急性重症胰腺炎 SIRS systemic inflammatory 全身炎症反应综合征 response syndrome TBK1 TANK binding kinase-1 TANK-结合酶 1 TRAF-6 TNF-receptor associated factor TNF 相关因子-6 TLR4 toll-like receptor 4 Toll 样受体 4 缩略词 英文名称 中文名称 TRIF TIR domain containing adaptor inducing interferon-β TIR 结构域衔接蛋白 PAGE PAGE 10 目 录 中文摘要 I Abstract II HYPERLINK \l _bookmark0 英 文 缩 略 词 IV HYPERLINK \l _bookmark1 目 录1 HYPERLINK \l _bookmark2 前 言2 HYPERLINK \l _bookmark3 第一章 材料与方法4 HYPERLINK \l _bookmark4 1.1 实验动物4 HYPERLINK \l _bookmark5 1.2 主要仪器4 HYPERLINK \l _bookmark6 1.3 主要试剂5 HYPERLINK \l _bookmark7 1.4 急性胰腺炎动物模型建