小剂量沙利度胺联合VED化疗方案治疗老年初发多发性骨髓瘤临床效果.docVIP

小剂量沙利度胺联合VED化疗方案治疗老年初发多发性骨髓瘤临床效果 　　[摘要]目的 探?小剂量沙利度胺联合VED化疗方案治疗老年初发多发性骨髓瘤的临床效果。方法 选取2011年7月～2016年6月我院收治的82例老年初发多发性骨髓瘤患者作为研究对象，随机分为试验组和对照组，各41例。对照组采用标准VED方案实施化疗，试验组采用小剂量沙利度胺联合标准剂量VED化疗方案治疗，比较两组的治疗总有效率、不良反应发生率以及治疗后的Karnofsky评分、血红蛋白指数、骨髓浆细胞数、血M蛋白情况。结果 试验组的总有效率为85.37%，显著高于对照组的63.41%，差异有统计学意义（P0.05）。经治疗后，患者的轻度嗜睡与便秘症状得到显著缓解，未对治疗造成影响。结论 对于老年初治多发性骨髓瘤患者，使用小剂量沙利度胺联合化疗方案的治疗方案安全有效，患者耐受性佳，具有很好的临床可行性，值得进一步推广应用。 　　[关键词]多发性骨髓瘤；药物治疗；化疗；沙利度胺；效果比较 　　[中图分类号] R738.1 [文献标识码] A [文章编号] 1674-4721（2016）12（c）-0063-04 　　Clinical effect of low dose Thalidomide combined with VED chemotherapy in the treatment of elderly patients with newly diagnosed multiple myeloma 　　LIN Zhi-juan LUO Yi-ming 　　Department of Hematology，the First Affiliated Hospital of Xiamen University，Xiamen 361003，China 　　[Abstract]Objective To explore the clinical effect of low dose Thalidomide combined with VED chemotherapy in the treatment of elderly patients with newly diagnosed multiple myeloma.Methods 82 elderly patients with newly multiple myeloma in our hospital from July 2011 to June 2016 were selected and randomly divided into the experimental group and the control group，41 cases in each group.The control group was treated with standard VED regimen chemotherapy，the experimental group was treated with low-dose Thalidomide combined with standard dose chemotherapy of VED.The total effective rate，the incidence rate of adverse reaction，Karnofsky score after treatment，hemoglobin index，bone marrow plasma cell count，and serum M protein were compared between the two groups.Results The total effective rate of the experimental group was 85.37%，which was higher than 63.41% of the control group，with significant difference （P0.05）.After treatment，the patient′s symptoms of mild sleepiness and constipation were significantly alleviated，which did not affect the treatment.Conclusion For elderly patients with newly diagnosed multiple myeloma，the application of low dose Thalidomide combined with chemotherapy is safe and effective，