不同分度急性胰腺炎患者早期凝血功能的变化和意义-内科学(消化系病)专业论文.docxVIP

万方数据 万方数据 Ca2+与 APACHE II 评分无线性相关关系；MSAP 组 PT、APTT、FIB、INR 与 APACHE II 评分无线性相关关系；MSAP 组 Ca2+与 APACHE II 评分呈负相关。 SAP 组 PT、APTT、INR 与 APACHE II 评分无线性相关关系，SAP 组 FIB 与 APACHE II 呈正相关，SAP 组 Ca2+与 APACHE II 呈负相关。结论：1.在新的不 同分度急性胰腺炎患者中 FIB、Ca2+与胰腺炎的病情严重程度相关。2.急性胰腺 炎患者早期就存在不同程度的凝血功能及血浆钙离子的异常，特别在 MSAP、 SAP 患者中凝血功能改变更为明显；提示在早期检测凝血功能可能对评估病情严 重程度有一定意义。3.急性胰腺炎患者 APACHE II 评分越高，提示急性胰腺炎病 情越重，但国内外在 MSAP 及 SAP 中，APACHE II 评分目前尚无明确的界限。 不同凝血指标如何影响胰腺炎所致凝血障碍的发生、发展，在急性胰腺炎的哪个 阶段进行干预可以更好的预防和治疗凝血功能障碍，如何利用 APACHE II 评分 区分 SAP 及 MSAP，这都需要做进一步的研究。 【关键词】：急性胰腺炎、APACHE II 评分、凝血功能、Ca2+ III The Significance and Changes of blood coagulation System in the early stage of the Different Degree patients with Acute Pancreatitis Major : Medicine Master： Deng Wanhang Tutor: Li Zhou Qi Liu Objective：To explore the significance and changes of blood coagulation function in the early stage of the different Degree patients with acute pancreatitis after Atlanta International Acute Pancreatitis new degree in 2012, and provide the Theoretical guidance for early prevention and correct to the blood coagulation disorders caused by pancreatitis.Methods: Select 133 patients with acute pancreatitis within 24 hours from the department of gastroenterology and the department of hepatobiliary surgery of affiliated hospital of guiyang medical college and baiyun affiliated hospital of guiyang medical college from october 2012 to march 2015. Neither patients with malignant tumors nor patients with oral anticoagulant therapy was selected. According to the Clinically Based Classification System in 2012 in Atlanta, the acute pancreatitis was divided into mild acute pancreatitis(MAP) group with 49 patients, moderately severe acute pancreatitis(MSAP)group with 30 patients and severe acute pancreatitis(SAP)group with 54 patients. In the control group (30), people were all healthy with non-hemorrhagic diseases nor thrombotic diseases, and had not taken any medicine 2 weeks before test. The fasting venous blood of all subjects were obta