参附注射液治疗老年慢性心力衰竭的临床观察-内科学专业论文.docxVIP

参附注 参附注射液治疗老年慢性心力衰竭的临床观察 - - PAGE 10 - - - PAGE 13 - 摘要 目的：本研究通过心肾阳虚的心力衰竭患者在常规心力衰竭治疗基础上静脉 使用 50ml 和 80ml 参附注射液与常规心力衰竭治疗对照，对比三者用药前后组 间心功能变化情况，观察三组间生化，Nt-proBNP 及心超心功能指标的变化，评 价参附注射液的临床疗效和安全性。 方法：本研究收集了 2012 年 3 月至 2013 年 10 月期间在上海市中西医结合 医院心内科、心内科重症监护室住院病人，且临床确诊为 CHF 的病人，中医症 候分型为心肾阳虚证患者。将符合纳入标准的 117 例慢性心衰病人按照随机数字 表方法分为对照组、参附 50ml 组和参附 80ml 组，三组的一般治疗相同，参附 50ml 组和参附 80ml 组在一般治疗基础上加用参附注射液治疗，14 天后进行患 者相关指标观察。 结果：参附治疗组和常规药物治疗组治疗前后心功能状态均有不同程度的改 善，参附治疗组在降低 ET-1、Nt-proBNP 水平和降低 Lee 心衰积分方面较常规药 物治疗组有显著差异（P＜0.05），组间提示降低 ET-1、Nt-proBNP 及 LEE 心衰 积分方面未见明显差异（P＞0.05）；参附治疗组在改善 SV 和 EF 方面较对照组 有显著差异（P＜0.05），组间对照同样提示未见显著差异（P＞0.05）；对照组治 疗有效率为 52.78%，参附 50ml 组治疗有效率为 71.05%，参附 80ml 组治疗有效 率为 89.47%，且参附治疗组对比常规治疗组均有显著性差异（P＜0.05）。 结论：参附注射液治疗慢性心力衰竭具有较好的临床疗效，且无明显不良反 应。 关键词：参附注射液，心力衰竭，临床观察 Clinical observation of Shenfu in elder patients with chronic heart failure Abstract Objective:In this study, the patients with heart failure were divided into three groups.The first group used the conventional treatment, the second group used Shenfu 50ml based on conventional treatment, the thrid group used Shenfu 80ml based on the conventional treatment.We compared with changes of cardiac function before and after treatment in three groups,and observed three groups of biochemical,changes of Nt-proBNP and cardiac function indexes in order to evaluate the clinical efficacy and safety of Shenfu injection Method:The study collected patients,diagnosed as CHF patients,TCM syndrome typing for heart patients with kidney yang deficiency syndrome,who stayed.in Shanghai TCM-intergrated Hospital during the period from March 2012 to October 2013.The 117 patients meeting inclusion criteria of chronic heart failure patients were randomly divided into control group, Shenfu 50ml group and Shenfu group 80ml.The general treatment of three groups was same.Shenfu group 50ml and Shenfu 80ml combined with Shenfu injection treatment.Three groups were observed the relevant biochemical index after 14 days. Results:Shenfu treatment gro