序贯疗法与标准四联疗法治疗胃溃疡临床分析.docVIP

序贯疗法与标准四联疗法治疗胃溃疡临床分析 　　摘要：目的 探究序贯疗法与标准四联疗法治疗胃溃疡的临床效果，并评价两种方法的安全性。方法 从我院收治的胃溃疡的患者中选取76例作为研究对象，随机分为两组，实验组应用序贯疗法治疗，对照组应用标准四联疗法治疗，治疗后，比较两组患者的治疗效果，不良反应发生率，Hp（幽门螺旋杆菌）根除率，以及停药后胃溃疡的复发率。结果 实验组治疗有效率明显高于对照组；实验组治疗过程中副作用的发生率明显低于对照组；治疗后6个月，实验组有2例复发，对照组有6例复发；组间数据差异显著，P0.05，有统计学意义。实验组的Hp根除率为37（97.37%），对照组为32（84.21%），两组相比差异具有统计学意义（P0.05）。结论 胃溃疡四联疗法治疗中采用序贯四联疗法治疗，具有较为显著的临床意义，安全性较高，值得在临床推广应用。 　　关键词：雷贝拉唑；奥美拉唑；胃溃疡 　　中图分类号：R573.1 文献标识码：A 文章编号：1006-1959（2017）13-0010-02 　　Abstract：Objective To explore the clinical effect of sequential therapy and standard quadruple therapy in treatment of gastric ulcer，and evaluate the safety of two methods.Methods From our hospital in 76 cases of gastric ulcer patients as the research object，randomly divided into two groups，the experimental group used sequential therapy，the control group using standard quadruple therapy，after treatment，compared two groups of patients，the incidence of adverse reactions，Hp（Helicobacter pylori）eradication rate，and after discontinuation of gastric ulcer recurrence rate.Results The effective rate of the treatment group was significantly higher than the control group；the side effects during the treatment of the experimental group were significantly lower than the control group；6 month after treatment，the experimental group had 2 cases of recurrence，6 cases in the control group had recurrence；data between group differences were significant，P0.05，have statistical significance.The experimental group Hp eradication rate was 37 （97.37%），the control group was 32（84.21%），with statistically significant difference between the two groups（P0.05）.Conclusion Sequential quadruple therapy is effective in the treatment of gastric ulcer quadruple therapy，which is of great clinical significance and high safety.It is worthy to be popularized in clinical application. 　　Key words：Rabeprazole；Omeprazole；Gastric ulcer 　　胃?⒀袷粲诹俅采系某＜?、多发疾病。随着时代不断发展，工作压力的增加，人们的饮食也越来越不规律，导致胃溃疡的发病率呈逐年上升趋势，胃溃疡患者一般临床表现为胃部疼痛、恶心、呕吐、反酸等，极大影响了患者的正常工作和生活[1]。目前治疗胃溃疡最主要的方法为药