幽门螺杆菌感染对肝性脑病患者血清二胺氧化酶内毒素水平影响.docVIP

幽门螺杆菌感染对肝性脑病患者血清二胺氧化酶内毒素水平影响 　　【摘要】 目的 探讨幽门螺杆菌感染对肝性脑病患者血清二胺氧化酶、内毒素水平的影响。方法 45例肝硬化合并肝性脑病患者， 按照14碳尿素呼气试验结果分为幽门螺杆菌感染组（24例）及对照组（21例）。幽门螺杆菌感染组为幽门螺杆菌阳性合并肝性脑病患者， 对照组为幽门螺杆菌阴性合并肝性脑病患者， 分别记录两组患者血清二胺氧化酶、内毒素水平情况以及幽门螺杆菌感染与肝性脑病程度分级情况， 并进行比较。结果 治疗2周后， 幽门螺杆菌感染组二胺氧化酶（56.32±10.21）U/ml、内毒素水平（80.57±30.28）EU/ml明显高于对照组的（32.65±8.54）U/ml、（45.75±13.24）EU/ml（P0.05）；幽门螺杆菌感染组血氨水平在不同肝性脑病程分级明显高于对照组（P0.05）。结论 幽门螺杆菌感染可以使肝性脑病患者血清二胺氧化酶、内毒素明显增高。 　　【关键词】 幽门螺杆菌；肝性脑病；血清二胺氧化酶；内毒素；影响 　　DOI：10.14163/j.cnki.11-5547/r.2016.31.010 　　【Abstract】 Objective To investigate influence by helicobacter pylori infection on serum diamine oxidase and endotoxin levels in hepatic encephalopathy patients. Methods A total of 45 liver cirrhosis complicated with hepatic encephalopathy patients were divided by 14C urea breath test outcomes into helicobacter pylori infection group （24 cases） and control group （21 cases）. The helicobacter pylori infection group contained helicobacter pylori positive cases with complicated hepatic encephalopathy， and the control group contained helicobacter pylori negative cases with complicated hepatic encephalopathy. Record and comparison were made on serum diamine oxidase and endotoxin levels， helicobacter pylori infection and hepatic encephalopathy grade. Results After 2 weeks of treatment， the helicobacter pylori infection group had all higher diamine oxidase as （56.32±10.21） U/ml and endotoxin as （80.57±30.28） EU/ml than （32.65±8.54） U/ml and （45.75±13.24） EU/ml in the control group （P0.05）. The helicobacter pylori infection group had obviously higher blood ammonia levels in different hepatic encephalopathy grades than the control group （P0.05）. Conclusion Helicobacter pylori infection leads to remarkable increase of serum diamine oxidase and endotoxin levels in hepatic encephalopathy patients. 　　【Key words】 Helicobacter pylori； Hepatic encephalopathy； Serum diamine oxidase； Endotoxin； Influence 　　近年?硌芯糠⑾郑? 肝硬化患者极易发生腹膜感染、肝性脑病、腹腔积液等并发症， 这些情况与肠道黏膜损伤、菌群紊乱有直接关系。其中， 肝性脑病是以意识障碍主要表现形式的中枢神经功能