序贯无创机械通气在稳定期重度COPD患者肺康复治疗中应用.docVIP

序贯无创机械通气在稳定期重度COPD患者肺康复治疗中应用 　　[摘要]目的 探究序贯无创机械通气对稳定期重度慢性阻塞性肺疾病（COPD）患者肺康复的临床疗效。方法 选取2011年11月～2016年11月我院收治的80例稳定期重度COPD患者，按随机数字表法分为观察组40例（常规肺康复治疗联合序贯无创机械通气治疗）和对照组40例（常规肺康复治疗），比较两组患者肺功能、血气分析指标和生活质量水平。结果 治疗后观察组患者FEV1/FVC、PaO2、PaCO2、pH、RR水平均显著优于治疗前，且改善程度优于对照组，差异有统计学意义（P0.05）；治疗后观察组患者QOL评分、6MWD、Borg呼吸困难评分均显著优于治疗前，且改善程度优于对照组，差异有统计学意义（P0.05）。结论 序贯无创机械通气治疗联合肺康复治疗可以显著改善稳定期重度COPD患者肺功能和缺氧症状，调节机体酸碱平衡，提高患者生活质量水平和活动耐力，值得临床推广应用。 　　[关键词]序贯无创机械通气；稳定期重度COPD患者；肺康复；治疗 　　[中图分类号] R563.9 [文献标识码] A [文章编号] 1674-4721（2017）05（b）-0024-03 　　Application of sequential non-invasive mechanical ventilation in pulmonary rehabilitation of patients with stable severe COPD 　　PENG Yong-sheng1 LAI Yong-hui1 ZHU Qi-cheng2 　　1.Department of ICU，the First People′s Hospital of Nankang District in Jiangxi Province，Ganzhou 341400，China；2.Department of Respiratory ，the First People′s Hospital of Nankang District in Jiangxi Province，Ganzhou 341400，China 　　[Abstract]Objective To investigate the clinical effect of sequential non-invasive mechanical ventilation in pulmonary rehabilitation of patients with stable chronic obstructive pulmonary disease （COPD）.Methods A total of 80 patients with stable severe COPD treated in our hospital from November 2011 to November 2016 were randomly divided into the observation group （n=40，given routine pulmonary rehabilitation combined with sequential noninvasive mechanical ventilation treatment） and the control group （n=40，given routine pulmonary rehabilitation）.Pulmonary function， blood gas analysis indexes and quality of life were compared between the two groups.Results After treatment， the levels of FEV1/FVC， PaO2，PaCO2， pH and RR in the observation group were significantly better than those before treatment， and the improvement was better than that in the control group （P0.05）. After treatment， QOL score， 6 MWD and Borg score in the observation group were significantly better than those before treatment， and the improvement was better than that in the control group （P0