微创经皮肾镜碎石取石术治疗感染性肾结石疗效及对血清hs―CRP水平结石清除率和肾功能影响.docVIP

微创经皮肾镜碎石取石术治疗感染性肾结石疗效及对血清hs―CRP水平结石清除率和肾功能影响 　　【摘要】 目的：比较微创经皮肾镜取石术（MPCNL）与标准通道经皮肾镜取石术（PCNL）治疗感染性肾结石的效果及对血清超敏C反应蛋白（hs-CRP）水平、结石清除率和肾功能的影响。方法：选取2012年 　　10月-2017年7月本院诊治的感染性肾结石患者80例，按照随机数字表法分为观察组和对照组，各40例。观察组采用MPCNL治疗，对照组采用PCNL治疗，比较两组手术时间、术中出血量、手术前后的肌酐和hs-CRP水平、结石清除率及并发症情况。结果：术后，两组肌酐、hs-CRP水平均高于术前（P0.05）；观察组一次性结石清除率为65.00%（26/40），低于对照组的85.00%（34/40），比较差异有统计学意义（P0.05）。结论：对于感染性肾结石患者而言，PCNL一次性结石清除率更高，但MPCNL对肾功能损伤更小，且术后炎症反应较轻，值得推广。 　　【关键词】 感染性肾结石； 微创经皮肾镜取石术； 炎症反应； 肾功能 　　【Abstract】 Objective：To compare the efficacy of minimally invasive percutaneous nephrolithotomy（MPCNL） and standard channel percutaneous nephrolithotomy（PCNL） for the treatment of infectious kidney stones and its effects on serum high sensitivity C reactive protein（hs-CRP） level，stone clearance rate and renal function.Method：A total of 80 patients with infectious kidney stones who were treated in our hospital from October 2012 to July 2017 were selected，according to the random number table method，they were divided into observation group and control group，40 cases in each group.The observation group was treated with MPCNL，and control group was treated with PCNL.The operation time，intraoperative amount of bleeding，the levels of creatinine and hs-CRP before and after operation，stone clearance rate and complications of two groups were compared.Result：After operation，the levels of creatinine and hs-CRP in two groups were higher than those of before operation（P0.05）.The disposable stone clearance rate in observation group was 65.00%（26/40），which was lower than 85.00%（34/40） of the control group，and the difference was statistically significant（P0.05）.Conclusion：For patients with infectious kidney stones，the PCNL disposable stone clearance rate is higher，but MPCNL has less damage to the renal function，and the postoperative inflammatory reaction is mild，it is worth promoting. 　　【Key words】 Infectious kidney stones； MPCNL； Inflammatory reaction； Renal function 　　First-author’s address：The Second Hospital of Xin