急诊PCI对AMI患者血浆P选择素和hsCRP水平影响.docVIP

急诊PCI对AMI患者血浆P选择素和hsCRP水平影响 　　【摘要】 目的 探讨AMI患者急诊冠脉介入治疗（PCI）前后血浆P-选择素和高敏C反应蛋白（hs-CRP）水平变化的意义及与冠脉病变程度的相关性。方法 110例AMI患者分为急诊PCI治疗组58例和非急诊PCI治疗组52例，分别于入院即刻、入院24 h和4周进行血浆P-选择素和hs-CRP水平检测，急诊PCI组于PCI术中行冠脉造影确定冠状动脉病变数目；分析两组在入院不同时间血浆P-选择素和hs-CRP水平变化的差异及急诊PCI组血浆P-选择素和hs-CRP水平与冠脉病变程度的相关性。结果 两组患者血浆P-选择素和hs-CRP水平在入院即刻无显著性差异（P＞0.05），而在入院24 h和4周有显著性差异（P＜0.05）；急诊PCI组中单支病变患者P-选择素和hs-CRP水平明显低于双支和三支病变患者（P＜0.05）。结论 PCI可导致体内P-选择素和hs-CRP表达增加，而且P-选择素和hs-CRP水平与冠脉病变程度存在明显的相关性；PCI术前检测血浆P-选择素和hs-CRP水平对于AMI患者冠状动脉病变程度的预先判断具有一定的指导意义。 　　【关键词】 急性心肌梗死； 急诊PCI； P-选择素； 高敏C反应蛋白 　　Influence of the level of P-selectin and high sensitive C-reflective proteins on the patients with actue myocardial infarction by emergency percutaneous coronary intervention ZHANG Ming-ji, WANG Gang, WANG Li, CHEN Ke-quan, ZHANG Tong-yan.Anshan Central Hospital, Anshan 114000,China 　　【Abstract】 Objective To approach the significance between P-selectin and the change level of high sensitive C-reflective proteins of the treatment anterior-posterior of the emergency percutaneous coronary intervention of patients of actue myocardial infarction which is connected with the degree of coronary artery disease.Methods 110 patients with actue myocardial infarction were observed,separated 58 cases who accept the treatment of emergency percutaneous coronary intervention and 52 cases who are not treated with it.The concentration of P-selectin and the level of hsCRP were measured at the moment,24 hours and a month when they admission to hospital.The numbers of blood vessels of coronary artery disease diagnosed by coronary angiography with the treatment group of the emergency percutaneous coronary intervention.To analyze the difference between P-selectin and the vary level of hsCRP at different time,simultaneously,to analyze the relations between P-selectin and hsCRP of the treatment group of emergency percutaneous coronary intervention with the degree of coronary artery disease.Results 58 patients are obtain to success by the operation of