急性冠脉综合征患者PCI术后血IL―37hs―CRP变化及意义.docVIP

急性冠脉综合征患者PCI术后血IL―37hs―CRP变化及意义 　　【摘要】 目的：评价急性冠脉综合征患者PCI术后血IL-37、hs-CRP的变化及意义。方法：选取2014年1月-2015年5月在本院行PCI治疗的60例急性冠脉综合征患者为PCI组，同时选30例健康体检者作为对照组。对入选者行IL-37，hs-CRP检测。PCI组随访12个月，收集整理患者临床资料进行分析。结果：PCI组患者血浆IL-37水平较对照组低，而hs-CRP水平高于对照组，两组比较差异有统计学意义（P0.05）。PCI术后24 h，血浆hs-CRP升高，血浆IL-37没有增加。PCI术后有并发症组hs-CRP较高，IL-37表达较长时间保持在低水平。结论：PCI术后不良心血管事件的发生与患者体内抗炎/促炎因子失衡有关。IL-37和hs-CRP的变化可作为判断PCI术后炎症反应强弱的指标。 　　【关键词】 急性冠脉综合征； 经皮冠状动脉介入治疗（PCI）； IL-37； hs-CRP 　　【Abstract】 Objective：To evaluate the changes and significance of serum IL-37 and hs-CRP in patients with acute coronary syndrome（ACS） after PCI.Method：From January 2014 to May 2015，60 cases with acute coronary syndrome who received PCI treatment as the treatment group and 30 cases of healthy persons as control group.Serum IL-37 and hs-CRP of the two groups were detected.PCI group was followed up for 12 months.The clinical data of two groups were collected and analyzed.Result：The plasma IL-37 level in the PCI group was lower than that in the control group，while the level of hs-CRP was higher than that of the control group，the differences were statistically significant（P0.05）.24 hours after PCI，the plasma hs-CRP increased and plasma IL-37 did not increase，hs-CRP was higher in patients with complications after PCI，and the expression of IL-37 was maintained at a low level for a long time，the differences were statistically significant（P0.05）Conclusion：The occurrence of adverse cardiovascular events after PCI is related to the imbalance of anti-inflammatory and proinflammatory cytokines in patients.The changes of IL-37 and hs-CRP can be used as indicators to judge the inflammatory response after PCI. 　　【Key words】 Acute coronary syndrome； Percutaneous coronary intervention （PCI）； IL-37； hs-CRP 　　First-author’s address：Shenzhen Nanshan District People’s Hospital，Shenzhen 518052，China 　　doi：10.3969/j.issn.1674-4985.2017.13.032 　　?皮冠状动脉介入治疗（PCI）在急性冠脉综合征（acute coronary syndrome，ACS）中已常规使用，PCI术后不良事件与炎症反应密切相关。本研究通过测定ACS患者PCI术前后IL-37、hs-CRP