米非司酮治疗糖尿病患者更年期功能性子宫出血疗效研究.docVIP

米非司酮治疗糖尿病患者更年期功能性子宫出血疗效研究 　　[摘要] 目的 探讨米非司酮治疗糖尿病患者更年期功能性子宫出血的效果。方法 选取该科2015年1月―2017年1月收治的糖尿病合并更年期功能性子宫出血妇女110例，随机分为两组各55例，观察组给予米非司酮，对照组给予妈富隆，比较疗效。结果 观察组总有效率为96.4%，明显优于对照组87.3%（P0.05）；观察组控制出血时间（27.93±6.47）h、出血完全停止时间（50.81±5.90）h，明显短于对照组（P0.05）。结论 米非司酮治疗糖尿病患者更年期功能性子宫出血效果显著，值得应用。 　　[关键词] 米非司酮；糖尿病；更年期功能性子?m出血 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2017）08（b）-0057-02 　　Research on Curative Effect of Mifepristone in Treatment of Menopause Dysfunctional Uterine Bleeding of Diabetes Patients 　　ZHAO Qing-jun 　　Family Planning Department， Changchun Obstetrics and Gynecology Hospital， Changchun， Jilin Province， 130000 China 　　[Abstract] Objective To study the effect of mifepristone in treatment of menopause dysfunctional uterine bleeding of diabetes patients. Methods 110 cases of women with diabetes and menopause dysfunctional uterine bleeding admitted and treated in our hospital from January 2015 to January 2017 were selected and randomly divided into two groups with 55 cases， the observation group and the control group were respectively treated with mifepristone and marvelon， and the curative effect was compared betwen the two groups. Results The total effective rate in the observation group was obviously better than that in the control group（96.4% vs 87.3%）（P0.05）， and the bleeding control time， complete stop time of bleeding in the observation group were respectively（27.93±6.47）h and（50.81±5.90）h， which were obviously shorter than those in the control group（P0.05）. Conclusion The effect of mifepristone in treatment of menopause dysfunctional uterine bleeding of diabetes patients is obvious， which is worth application. 　　[Key words] Mifepristone； Diabetes； Menopause dysfunctional uterine bleeding 　　功能性子宫出血是临床常见的妇科疾病，多是由于生殖内分泌轴功能紊乱而引起的异常子宫出血，其中约50%的功血发生在更年期[1]。糖尿病是一种危害人类生命的顽固疾病，尤其对更年期女性来说，糖尿病会使更年期提前的可能性增加3倍[2]。妇女更年期后，卵巢功能衰退，性激素分泌减少，促性腺激素升高，雌激素水平出现较大波动，引起子宫内膜不完整脱落，发生不规则子宫出血，致月经周期失去正常规律，经量过多，经期延长，同时也对妇女心理和生理健康造成影响。为提高对糖尿病患者更年期功能性子宫出血的治疗效果，该科对2015年1月―2017年1月收治的糖尿病