性激素及SOD水平与女性黄褐斑相关性分析.docVIP

性激素及SOD水平与女性黄褐斑相关性分析 　　【摘要】 目的：探讨性激素及SOD水平与女性黄褐斑的相关性。方法：选取本院2014年1月-2017年 　　1月收治的100例女性黄褐斑患者为观察组，另选取同期本院健康体检女性30例为对照组。测定并比较两组血清中的促黄体生成激素（LH）、促卵泡刺激素（FSH）、雌二醇（E2）、睾酮（T）、孕酮（P）与垂体泌乳素（PRL）等性激素及超氧化物歧化酶（SOD）、促黑素细胞激素释放激素（MSH）、过氧化脂质（LPO）的水平。结果：观察组的血清LH、FSH与E2水平均高于对照组，T水平低于对照组，差异均有统计学意义（P0.05）；观察组的SOD水平低于对照组，LPO与MSH水平均高于对照组，差异均有统计学意义（P0.05）。结论：女性黄褐斑的形成与性激素的异常存在一定相关性，患者血清的FSH、E2、P水平均高于正常，但性激素紊乱并不一定是造成黄褐斑形成的直接原因；SOD与黑素的产生相关，其水平的下降可造成相关代谢的失衡，使黑素生成过多引发黄褐斑。 　　【关键词】 性激素； SOD； 女性黄褐斑； 相关性 　　Correlation Analysis of Sex Hormones and SOD Levels with Female Chloasma/ZHANG Wei-long，XIE Guo-lie，LI Xiao-hua，et al.//Medical Innovation of China，2017，14（15）：107-110 　　【Abstract】 Objective：To investigate the relationship between sex hormones and SOD level with the female chloasma.Method：From January 2014 to January 2017，100 female patients with chloasma in our hospital were selected as the observation group，30 healthy women were selected as the control group.The serum luteinizing hormone（LH），follicle stimulating hormone（FSH），estradiol（E2），testosterone（T） and progesterone（P） and prolactin（PRL） and superoxide dismutase（SOD），melanocyte stimulating hormone releasing hormone （MSH），lipid peroxidation（LPO）levels of the two groups were measured and compared.Result：The serum levels of LH，FSH and E2 in the observation group were higher than those in the control group，the levels of T was lower than that in the control group，the differences were statistically significant（P0.05），the level of SOD in the observation group was lower than that in the control group，the levels of LPO and MSH of the observation group were higher than those of the control group，the differences were statistically significant（P0.05）.Conclusion：There is a certain correlation between abnormal formation of female chloasma and sex hormone，serum FSH，E2 and P levels of the chloasma patient are significantly higher than those in normal，but sex hormone disorder does not determine as directly formation factor of chloasma；the decline of S