性激素和精神分裂症性别差异及认知功能相关性研究.docVIP

性激素和精神分裂症性别差异及认知功能相关性研究 　　[摘要] 目的 探讨性激素和精神分裂症患者性别差异及认知功能的相关性。 方法 随机选取2013年5～12月在我院就诊的60例女性和20例男性精神分裂症患者，收集患者的一般资料，并进行数字广度测验（DST）和连线测验（TMT）的认知功能检测，将结果和性激素水平进行相关分析。 结果 首次发病年龄、病程、文化程度、抗精神病药物治疗效果存在性别差异（P0.05）。男、女性患者的雌激素水平和数字广度-顺背（DSF）呈正相关，和连线测验A、B（TMTA、TMTB）呈负相关。男性患者的睾酮水平和TMTA、TMTB呈负相关。 结论 雌激素可能和精神分裂症的性别差异有关，雌激素与睾酮和认知功能也有一定的相关性。 　　[关键词] 精神分裂症；性激素；性别；认知功能 　　[中图分类号] R749.3 [文献标识码] B [文章编号] 1673-9701（2015）35-0077-04 　　[Abstract] Objective To investigate the connection between sex hormones and gender differences and cognitive function in patients with schizophrenia. Methods A total of 80 eligible patients including 60 female and 20 male with schizophrenia conducted general information collection and Digit Span Task（DST） and Trial Making Test （TMT） measurement. The data o f the schizophrenic patients were collected and analyzed with sex hormones. Results There were significant differences between male and female schizophrenic patients in the age of first onset， course of disease，degree of education and antipsychotic treatment effects（P0.05）. The digit span-forward Task（DSF） score of female patients was higher than that of male patients， TMTA and TMTB were lower than those of male patients（P0.05）. In both male and female schizophrenic patients， E2 level was positively related to the age of first onset， and degree of education， otherwise，it was negatively related to the course of disease and antipsychotic treatment effects. In male patients，there was no connection between T level and the age of first onset， course of disease，degree of education and antipsychotic treatment effects. The estrogen level of male and female patients was positively correlated with the DSF and was negatively related to the TMTA and TMTB. The testosterone level of male patients was negatively correlated with the TMTand TMTB. Conclusion Estrogen may be related to gender differences in schizophrenia. Estrogen and testosterone have a certain correlation with cognitive function. 　　[Key words] Schizop