中药川芎血清药化学及透血脑屏障化学成分分析-analysis of serum drug chemistry and blood - penetrating brain barrier chemical composition of ligusticum chuanxiong hort.docxVIP

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中药川芎血清药化学及透血脑屏障化学成分分析-analysis of serum drug chemistry and blood - penetrating brain barrier chemical composition of ligusticum chuanxiong hort.docx

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中药川芎血清药化学及透血脑屏障化学成分分析-analysis of serum drug chemistry and blood - penetrating brain barrier chemical composition of ligusticum chuanxiong hort

成都中医药大学硕士学位论文─中药川芎血清药化学及透血脑屏障化学成分研究成都中医药大学硕士学位论文─中药川芎血清药化学及透血脑屏障化学成分研究 - - 4 - phthalate、Palmitic acid、Stearic acid originally existed in the Rhizoma chuanxiong. Isolation of the active compouds from Ligusticum chuanxiong Hort． The ethyl acetate extracted fraction could restrain the conglomeration of blood platelet according as the dose,which could be indicated it was the effective fraction. By the means of systematic solvent extraction, column chromatograph and re-crystallized, 3 compounds have been gained by separated and purified from the ethyl acetate extracted fraction of Rhizoma chuanxiong. Adopted the spectrum analysis and the literature information, chemical structures of 3 components have been identified, which are Ferulic acid, Caffeic acid, Vanillic acid. Reasonability of total ferulic acid for quality assessment of Rhizoma chuanxiong and determination of total ferulic acid by HPLC Founded on the literature, it was found that the determination of ferulic acid could rise after storing for several years. The main reason was that coniferyl ferulate in Rhizoma chuanxiong was found liable to hydrolyze into ferulic acid. Therefore, we discussed the reasonability of total ferulic acid for quality assessment of Rhizoma chuanxiong using a gradient program by HPLC-DAD and developed created a new HPLC method to quantitatively analyze total ferulic acid in Rhizoma chuanxiong. It would be referenced for improving the quality standard of Rhizoma chuanxiong. Key words: Rhizoma chuanxiong; Properties of TCM; Foundation of active components; Serum Pharmacochemistry; Blood brain barrier; Total ferulic acid; quality control - - 7 - 英文缩写词对照表 13C-NMR DAD 13C Nuclear magnetic resonance spectrum Diode array detector 碳-13 核磁共振谱二极管阵列检测器 1H-NMR Proton magnetic resonance spectrum 质子核磁共振谱 HPLC High performance liquid chromatography 高效液相色谱法 mp Melting point 熔点 GC/MS gas chromatography/Mass spectrometry 气相色谱－质谱联用法 LC/MS liquid chromatography/Mass spectrometry 液相色谱－质谱联用法 Rf Retardati