散结乳癖膏治疗卵巢囊肿模型大鼠实验研究.docVIP

散结乳癖膏治疗卵巢囊肿模型大鼠实验研究 　　【摘要】 目的：通过观察散结乳癖膏治疗卵巢囊肿模型大鼠在治疗前后血清中促黄体生成素及促卵泡刺激素含量，客观评价其治疗卵巢囊肿的疗效，为中医药治疗卵巢囊肿提供实验依据。方法：选取雌性未孕大鼠64只，采取手术的方法造模，从中选取造模成功大鼠，外敷散结乳癖膏（高、中、低剂量），连续6周，处死大鼠，观察移植物外观测量，取血后用放射免疫法检测大鼠体内促黄体生成素及促卵泡刺激素的含量。结果：散结乳癖膏可使模型大鼠的卵巢体积缩小，同时，散结乳癖膏高、中、低剂量组促黄体生成素及促卵泡刺激素含量与模型组比较，差异均有统计学意义（P0.05），结论：散结乳癖膏可降低大鼠血清中促黄体生成素及促卵泡刺激素的含量，对卵巢囊肿大鼠有一定的治疗作用，为今后临床用药提供新的思路。 　　【关键词】 散结乳癖膏； 卵巢囊肿； 促卵泡刺激素； 促黄体生成激素 　　Experimental Study of Sanjierupi Ointment for Ovarian Cyst Model Rats/HOU Hui-ling，JIN Jin-jian，GUAN Hong，et al.//Medical Innovation of China，2016，13（20）：033-035 　　【Abstract】 Objective：To evaluate the effects of Sanjierupi Ointment on ovariancyst in serum model rat by observing the content of luteinizing hormone and follicle-stimulating hormone before and after the treatment，in order to provide experimental basis.Method：The female unfertilized 64 rats were taken，using the surgical method to select the successful model rats.The building successful rats were selected and topical application of Sanjierupi Ointment in abdominal（high，middle and low doses），after 6 weeks，put to death in the rat，the execution of the grafts was observed and taken blood from eyes to detect LH and FSH by radioimmunoassav.Result：Sanjierupi Ointment reduced the model rat ovarian volume.At the same time，the content of LH and FSH of the high，middle and low doses group compared with the model control group，there had significant differences（P0.05）.Conclusion：Sanjierupi Ointment can reduce the content of LH and FSH，it has certain treatment function for ovarian cyst，and it can provide new ideas for future clinical treatment. 　　【Key words】 Sanjierupi Ointment； Ovarian cyst； Follicle-stimulating hormone； Luteinizing hormone 　　First-author’s address：Qiqihaer Medical University，Qiqihaer 161006，China 　　doi：10.3969/j.issn.1674-4985.2016.20.008 　　卵巢囊肿是一种常见的良性肿瘤[1]，常见于20～50岁妇女，中医称之为“肠覃”，性质和形态各有不同，多见为囊性囊肿，早期多无明显症状，常在妇科检查时偶然发现[2-3]，有一定的恶性比例，会引起内分泌失调、甲亢和多血症等[4-5]。目前，西医的治疗方法为手术切除[6]，即卵巢囊肿切除术，应用腹腔镜为主要的治疗手段[7-8]。对于大部分女性来说会造