新生儿败血症血清IL―6和PCT水平研究.docVIP

新生儿败血症血清IL―6和PCT水平研究 　　【摘要】 目的：探讨新生儿败血症时血清白细胞介素-6（IL-6）和降钙素原（PCT）水平的变化及临床意义。方法：选择50例临床诊断败血症的新生儿为观察组，同期选取50例非感染新生儿为对照组。采用ELISA法和免疫荧光发光法分别检测IL-6和PCT；比较两组的IL-6和PCT水平，以临床常用指标（IL-695.62 ng/L、PCT0.5 pg/ml）作为阈值判断标准，观察这两项指标对新生儿败血症的特异性、敏感性、阴性、阳性预测值及约登指数的诊断意义。结果：观察组治疗前IL-6、PCT水平与治疗后及对照组比较，差异均有统计学意义（P0.05），两个指标的联合诊断的灵敏度优于各指标的独立诊断。结论：新生儿败血症患儿血清IL-6和PCT水平在早期明显升高，对疾病的早期诊断具有重要意义；疑似败血症患儿应考虑多个指标联合应用，以提高诊断准确率。 　　【关键词】 新生儿败血症； 白细胞介素-6； 降钙素原 　　doi：10.14033/j.cnki.cfmr.2017.23.005 文献标识码 A 文章编号 1674-6805（2017）23-0010-03 　　Research on Serum IL-6 and PCT Level in Neonatal Septicemia/WEI Yi，YAN Zheng，HUANG Li-sen，et al.//Chinese and Foreign Medical Research，2017，15（23）：10-12 　　【Abstract】 Objective：To discuss changes of serum interleukin-6（IL-6） and procalcitonin（PCT） in neonatal septicemia and their clinical significance.Method：50 newborns diagnosed as septicemia were taken as the observation group and 50 non-infection newborns were taken as the control group.ELISA method and immunofluorescence method were used to detect IL-6 and PCT；IL-6 and PCT of the two groups were compared and clinical common indexes（IL-695.62 ng/L， 　　PCT0.5 pg/ml） were taken as the threshold judging criteria.The specificity，sensitivity，negative，positive predicating value of these two indexes to neonatal septicemia and the diagnosis significance of Youden index were observed.Result：IL-6 and PCT level of the observation group before the treatment were evidently higher than those of the control group and after the treatment，and the differences were statistically significant（P0.05）.The accuracy of combined diagnosis was better than that of independent diagnosis of each index.Conclusion：Serum IL-6 and PCT level of newborns with neonatal septicemia are evidently higher in the early stage，so they have great significance for the early diagnosis of the disease；for children who are suspected as septicemia，multiple indexes should be combined to improve the accuracy of the diagnosis. 　　【Key words】 Neonatal septicemia； Int