曲美他嗪细胞能量代谢作用对损伤心肌修复临床研究.docVIP

曲美他嗪细胞能量代谢作用对损伤心肌修复临床研究 　　【摘要】目的 探讨曲美他嗪药物的细胞能量代谢作用对酒精致损伤心肌的修复。方法 选取2013年～2014年我院收治的酒精性心肌病患者随机分成A组（对照组）和B组（曲美他嗪组），各15例。两组患者均同意戒酒，其中A组患者在戒酒的基础上给予酒精性心肌病的常规治疗及对症治疗，另B组患者在对照组治疗的基础上，给予曲美他嗪药物治疗。然后对两组患者用药前及用药后进行6 min步行实验和心脏超声进行心脏功能指标的量化，最后收集数据，并对两组患者的指标数据进行统计分析。结果 两组治疗前的 　　6 min步行距离和心脏超声测定的心脏功能指标对比，差异无统计学意义（P0.05）；两组分别组内治疗后4周6 min步行距离和心脏超声测定的心脏功能指标与用药前相比，差异均有统计学意义（P0.05）；两组治疗16周后的6 min步行距离和心脏功能指标组间比较，差异有统计学意义（P0.05）。结论 通过戒酒、常规治疗、及曲美他嗪治疗均可改善患者各项心脏功能指标，对心肌细胞有确定的保护及修复作用。 　　【关键词】酒精性心肌病；曲美他嗪；心脏功能指标；6 min步行距 　　【中图分类号】R541 【文献标识码】A 【文章编号】ISSN.2095-6681.2015.011.00.03 　　Clinical study about cardiacenerge metabolism effect of Trimetazidine on damaged myocardium 　　WANG Xiao-xu，FANG Cheng-cheng，WANG Fu-ping* 　　（Internal Medicine-Cardiovascular Department，Shandong Province Weihai City Municipal two Hospital，Shandong Weihai 264200，China） 　　【Abstract】Objective To objective cardiacenerge metabolism effect of Trimetazidine on damaged myocardium by alcohol. Methods 30 cases with alcoholic cardiomyopathy were randomly divided into A group and B group ，on the basis of quitting drinking ，they were given conwentional therapy and additional Trimetazidine for 16 weeks resprctively ，estimate therapeutic effect based on 6 min walking experiments ，left ventricular ejection fraction，heart motion amplitude，heart size. Results Before any treatment ，there were no difference between group A and group B（P0.05）；4 weeks later ，there were difference between before and after treatment in both group A and group B（P0.05）；16 weeks later，there were difference between group A and group B（P0.05）.compard with group A，the results of 6 min walking experiments and other cardiac function value are better in group B. Conclusion Additional Trimetazidine could improve cardiac fouction by improving cardiacenergy metabolism effect on alcohol cardiomyopathy patients，meantime，conventional therapy and abstimence also can help cardiac function recoverd. 　　【Key words】Alcohol cardiomyopathy；Trimetazidine ；6 min walking e