来氟米特对类风湿关节炎患者免疫调节与炎性状态影响研究.docVIP

来氟米特对类风湿关节炎患者免疫调节与炎性状态影响研究 　　【摘要】 目的：研究与观察来氟米特对类风湿关节炎患者免疫调节与炎性状态的影响情况。方法：选取2015年7月-2016年6月于本院进行治疗的70例类风湿关节炎患者为研究对象，根据随机数字表法分为对照组和观察组，每组各35例，对照组采用甲氨蝶呤进行治疗，观察?M在对照组的基础上加用来氟米特进行治疗，然后将两组患者治疗前后不同时间的免疫调节指标与炎性应激指标进行比较。结果：治疗前两组患者的免疫调节指标与炎性应激指标比较差异均无统计学意义（P0.05），而治疗后不同时间观察组的免疫调节指标与炎性应激指标均优于对照组，两组差异比较均有统计学意义（P0.05）结论：在甲氨蝶呤的治疗基础上，使用来氟米特治疗类风湿关节炎患者疗效较单永甲氨蝶呤更为显著，对免疫调节与炎性状态的影响更好，值得临床推广应用。 　　【关键词】 来氟米特； 类风湿关节炎； 免疫调节； 炎性状态 　　【Abstract】 Objective：To study and observe the influence of Leflunomide for the immunoregulation and inflammatory state of patients with rheumatoid arthritis. Method：70 patients with rheumatoid arthritis in our hospital from July 2015 to June 2016 were selected，they were divided into control group and observation group according to the method of random number table，35 cases in each group，the control group was treated with Methotrexate，the observation group was treated with Leflunomide on the basis of the control group，the immunoregulation indexes and inflammatory stress indexes of two groups at different time before and after the treatment were compared.Result：Before the treatment，the immunoregulation indexes and inflammatory stress indexes of two groups were no significant differences（P0.05），while the immunoregulation indexes and inflammatory stress indexes of observation group at different time after the treatment were all better than those of the control group，the differences were statistically significant（P0.05）.Conclusion：Compared with solely use Methotrexate，combined with Leflunomide in the treatment of patients with rheumatoid arthritis has better curative effect and impact in immune regulation and inflammatory state，so it is worthy of clinical application. 　　【Key words】 Leflunomide； Rheumatoid arthritis； Immunoregulation； Inflammatory state 　　First-author’s address：Shenzhen Hospital of Peking University，Shenzhen 518036，China 　　doi：10.3969/j.issn.1674-4985.2017.13.011 　　类风湿关节炎是一类以炎性滑膜炎为主要表现的疾病，本病患者的关节受累表现明显，严重者可导致关节畸形及功能丧失[1-2]，而对本类患者的相关研究显示，此类患者不仅