显影剂加温处理在CT增强扫描检查中应用效果.docVIP

显影剂加温处理在CT增强扫描检查中应用效果 　　[摘要] 目的 探讨显影剂加温处理应用于CT增强扫描检查的效果以及对不良事件发生率的影响。 方法 选取1300例接受CT增强检查的患者，将其随机分为加温组和常温组，每组650例，加温组于CT增强检查之前将显影剂加温到37℃之后再进行静脉注射（浓度：CT血管造影370 mg I/ml，动态增强300 mg I/ml），常温组的显影剂在20℃下直接进行静脉注射（浓度：CT血管造影370 mg I/ml，动态增强300 mg I/ml），比较两组患者不同温度下各浓度显影剂注射后的血管压力以及注射显影剂后变态反应和外渗的发生率。 结果 相同的温度下，注射显影剂的浓度越高，速度越快，其对血管造成的压力也就越大，差异有统计学意义（P0.05），在应用370 mg I/ml浓度的显影剂时，加温组患者在变态反应的发生率以及药物外渗率均明显低于常温组，组间比较差异有有统计学意义（0.81%比2.29%，1.62%比3.82%，P0.05）。 结论 加温处理对于低渗显影剂的变态反应发生率以及外渗率几乎无影响，而对于高渗显影剂，加温后可以显著降低变态反应发生率以及外渗率。 　　[关键词] 显影剂；加温；变态反应；外渗 　　[中图分类号] R981.1 [文献标识码] A [文章编号] 1674-4721（2015）06（c）-0062-03 　　[Abstract] Objective To explore the influence of effect and incidences of adverse reactions on contract agent by heating on computed tomography （CT） enhancement scan. Methods One thousand and three hundred patients accepted CT enhancement scan were evenly divided into heating group and room temperature group in random.In the heating group，contrast agent was warmed up to 37℃ and injected intravenously before CT enhancement scan （concentration： CT angiography was 370 mg I/ml， dynamic enhancement was 300 mg I/ml），while in the room temperature group，contrast agent was injected intravenously under room temperature of 20℃ （concentration： CT angiography was 370 mg I/ml， dynamic enhancement was 300 mg I/ml）. The vascular pressure after injection contrast agent by different concentration，incidence of allergic reaction and exosmosis rate in the two groups were compared. Results Under the same temperature，the higher concentration of injected contrast agent and faster the speed was，the greater vascular pressure was，which displayed a statistical difference （P0.05）.When 370 mg I/ml contrast agent was applied，incidence of allergic reaction and exosmosis rate in the heating group were both less than those in the room temperature group，which displayed statistical differences after inter-group comparison （0.81% vs 2.29% and 1.62% vs 3.82%，P 　　[Key words] Contrast agent； Heating； Allergic reacti