更昔洛韦治疗新生儿先天性巨细胞病毒感染临床观察.docVIP

更昔洛韦治疗新生儿先天性巨细胞病毒感染临床观察 　　[摘要] 目的 探讨更昔洛韦治疗新生儿先天性巨细胞病毒感染的临床效果。 方法 收集2012年2月～2013年4月来本院进行治疗的先天性巨细胞病毒感染的新生儿62例，按照随机数字表法分为观察组和对照组各31例。两组患儿均给予对症支持治疗，观察组采用更昔洛韦注射液治疗，对照组采用利巴韦林注射液治疗，比较两组的临床疗效及实验室指标的改善情况。 结果 观察组患儿治愈率为77.42%、好转率为9.68%、黄疸消退率为87.10%，均明显高于对照组的48.39%、19.35%、67.74%，两组差异有统计学意义（P0.05）。观察组的总胆红素（TBiL）、谷丙转氨酶（ALT）、谷草转氨酶（AST）水平较对照组明显低，差异有统计学意义（P0.05）。观察组患儿没有发现明显的不良反应。 结论 更昔洛韦治疗新生儿先天性巨细胞病毒感染效果满意，值得临床推广应用。 　　[关键词] 先天性巨细胞病毒感染；更昔洛韦；新生儿 　　[中图分类号] R722.1 [文献标识码] A [文章编号] 1674-4721（2013）11（c）-0087-02 　　Clinical observation of ganciclovir in the treatment of newborn congenital cytomegalovirus infection 　　WANG Qing 　　Xiangdong Hospital of Hunan Normal University，Liling 412200，China 　　[Abstract] Objective To explore the clinical effect of ganciclovir in the treatment of newborn congenital cytomegalovirus infection.Methods 62 cases of newborn with congenital congenital cytomegalovirus infection were collected from February 2012 to April 2013，and were randomly divided into the observation group （n=31） and the control group （n=31）.Two groups were given symptomatic and supportive treatment，the observation group was treated with ganciclovir injection，the control group was treated with ribavirin injection.The clinical effect and laboratory indexes of the two groups were compared.Results The cure rate in the observation group was 77.42%，the better rate was 9.68%，the jaundice subsided rate was 87.10%，was significantly better than 48.39%，19.35%，67.74% of the control group respectively，the difference was significant （P0.05）.TBiL，ALT，AST of the observation group was lower than that of the control group，the difference was significant （P0.05）.Adverse effects were not found in the observation group.Conclusion The effect of ganciclovir in the treatment of newborn congenital cytomegalovirus infection is better，it can be widely used in clinic. 　　[Key words] Congenital cytomegalovirus infection；Ganciclovir；Newborn infants 　　先天性巨细胞病毒感染是由人巨细胞病毒感染导致的人类感染性疾病，而我国具有较高的发病率，是较为常见的一种宫内感染，婴幼儿及小儿患有先