替扎尼定联合文拉法辛缓释片治疗紧张性头痛疗效分析.docVIP

替扎尼定联合文拉法辛缓释片治疗紧张性头痛疗效分析 　　[摘要] 目的 探讨替扎尼定联合文拉法辛缓释片治疗紧张性头痛的临床疗效。 方法 选取在我院神经科住院治疗的98例临床确诊的紧张性头痛患者，随机分为治疗组和对照组，每组49例，治疗组采用替扎尼定联合文拉法辛缓释片治疗，对照组采用替扎尼定治疗，两组均于治疗前、治疗后第2周、第4周分别采用视觉模拟评分法（VAS）记录疼痛分值，且于治疗结束前及治疗后用生活质量核心量表（QLQ-C30）对患者生活质量改善情况进行评定。 结果 治疗前治疗组及对照组VAS、QLQ-C30评分比较差异无统计学意义（P0.05）。治疗后第2周、第4周VAS评分与治疗前相比，结果示治疗组、对照组VAS评分差异均有统计学意义（P0.05），但治疗组VAS评分改善明显优于对照组，差异有统计学意义（P0.05）。治疗后第4周治疗组、对照组QLQ-C30评分与治疗前比较，差异有统计学意义（P0.05），但治疗组QLQ-C30评分改善优于对照组，差异有统计学意义（P0.05）。 结论 替扎尼定联合文拉法辛缓释片治疗紧张性头痛安全、可靠，值得临床推荐。 　　[关键词] 紧张性头痛；文拉法辛缓释片；替扎尼定；视觉模拟评分；生活质量核心量表 　　[中图分类号] R741 [文献标识码] B [文章编号] 1673-9701（2015）30-0082-03 　　Effectiveness of combination tizanidine tablets and venlafaxine slow release tablets in tension-type headache 　　SONG Wanzhi 　　Department of Neurology， Jiaozuo Tongren Hospital in Henan Province， Jiaozuo 454000， China 　　[Abstract] Objective To investigate the effect of tizanidine tablets and venlafaxine slow release tablets in treatment of tension-type headache. Methods A total of 98 patients with tension-type headache were randomly divided into the treatment group （n=49， treated with tizanidine tablets and venlafaxine slow release tablets） and the contral group （n=49， treated with tizanidine tablets）. The time of two groups were 4 weeks for a course of treatment. Visual analog scale （VAS） were measured before and after treatment 2 weeks， 4 weeks， quality of life questionnaire core-30 scores （QLQ-C30） were measured before and after treatment. Results The VAS， QLQ-C30 scores of two groups had no significant difference before treatment （P0.05）. The score of VAS in treatment groups and contral group after 2 weeks， 4 weeks treatment showed statistically significant differences compared with before treatment（P0.05）， but the score of VAS in the treatment group patients were significantly greater than the control group （P0.05）， which had a statistical significance. The score of QLQ-C30 in treatment groups and control group after 4 weeks treatment showed statistically significant differen