替格瑞洛在非ST段抬高型急性冠脉综合征中应用价值探讨.docVIP

替格瑞洛在非ST段抬高型急性冠脉综合征中应用价值探讨 　　[摘要] 目的 探讨替格瑞洛在非ST段抬高型急性冠脉综合征中的临床应用价值。方法 选择2015年5月～2016年11月本院收治的急性冠脉综合征患者80例，按照数字随机法分为两组，各40例，观察组使用阿司匹林100mg联合替格瑞洛90mg，每日两次，对照组使用阿司匹林100mg联合氯吡格雷75mg，每日1次，对所有患者随访6个月，比较两组干预后心房脑钠肽及纽约心功能变化，两组治疗前后血流储备分?担?FFR）值变化，统计两组预后情况。结果 干预后观察组心房脑钠肽水平低于干预前观察组及干预后对照组（P0.05），纽约心功能分级优于干预前观察组及干预后对照组（P0.05），FFR值显著低于对照组（P0.05），发生心力衰竭及心源性死亡比例均低于对照组（P0.05）。结论 针对急性冠脉综合征患者使用替格瑞洛治疗，能有效的改善患者心功能、减少严重并发症发生，进而提高临床治疗效果。 　　[关键词]替格瑞洛；非ST段抬高；急性冠脉综合征；心功能 　　[中图分类号] R543.3 [文献标识码] A [文章编号] 2095-0616（2017）16-217-04 　　Value of tigrine in non-ST-segment with acute coronary syndrome 　　LIU Zhen 　　Department of Cardiovascular， Xinwen Mining Group Limited Liability Company Center Hospital， Taian 271200， China 　　[Abstract] Objective To investigate the clinical value of tigrine non-ST-segment with acute coronary syndrome. Methods 80 cases with acute coronary syndromes from May 2015 to November 2016 were selected and randomly divided into two group. Patients in observation group were treated with aspirin 100 mg combined with tigrine 90mg， twice per day， and patients in control group were used aspirin 100mg combined with clopidogrel 75mg， once a day. All patients were followed up for 6 months， then atrial natriuretic peptide and heart function changes in New York， before and after treatment of blood flow reserve score（FFR） value changes and prognosis were compared. Results After treatment， the levels of atrial natriuretic peptide in the observation group were higher than before intervente and those in the control group（P0.05）. The heart function score of New York was better than before intervente and those in the control group（P0.05）. The FFR in the observation group was lower than control group（P0.05）. The proportion of heart failure and cardiac death in the observation group was significantly lower than control group（P0.05）. Conclusion The treatment of patients with acute coronary syndromes can improve the cardiac function and reduce the serious complication， and it can improve