标准大骨瓣减压术对重型颅脑损伤患者免疫功能及炎症反应影响.docVIP

标准大骨瓣减压术对重型颅脑损伤患者免疫功能及炎症反应影响 　　【摘要】目的：探究重型颅脑损伤患者采取标准大骨瓣减压术治疗对其免疫功能与炎症反应的影响。方法：选择2017年4月-2018年4月期间在商丘市第一人民医院神经外二科治疗的50例重型颅脑损伤患者作为研究对象，按随机数表法分成2组，各25例。对照组采取常规开颅手术，观察组采取标准大骨瓣减压术，比较两组术后免疫功能指标与炎性因子水平。结果：观察组IgA、IgM、CD3+、CD4+水平均较对照组高，IL-2与TNF-α水平较对照组低，IL-4水平高于对照组，差异有统计学意义（P005）。结论：标准大骨瓣减压术可显著改善重型颅脑损伤患者的免疫功能，降低炎症反应，降低颅内压，疗效确切。 　　【关键词】 重症颅脑损伤；标准大骨瓣减压术；免疫功能；炎症反应 　　【中图分类号】R742 　　【文献标志码】A 　　【文章编号】1005-0019（2018）06-030-01 　　Effect of standard large trauma craniotomy on immune function and inflammatory response in patients with severe craniocerebral injury 　　Li Jiandong （two Department of Neurosurgery， Shangqiu First Peoples Hospital， Shangqiu 476100， Henan） 　　Abstract Objective：To explore the effect of standard large trauma craniotomy on the immune function and inflammatory response in patients with severe craniocerebral injury.Methods： 50 cases of severe craniocerebral injury treated in two families of the Shangqiu First Peoples Hospital in April 2017 -2018 and April were selected as the subjects and divided into 2 groups according to the random number table method， and 25 cases each.The control group received conventional craniotomy， while the observation group received standard large bone flap decompression.The immune function and inflammatory factors were compared between the two groups after operation.Results： the level of IgA， IgM， CD3+ and CD4+ in the observation group was higher than that of the control group， and the level of IL-2 and TNF- alpha was lower than that of the control group， and the level of IL-4 was higher than that of the control group.The difference was statistically significant （P005）. Conclusion： standard large trauma decompression can significantly improve the immune function， reduce inflammatory reaction and reduce intracranial pressure in patients with severe craniocerebral injury. 　　Key words：Severe craniocerebral injury；standard large trauma craniotomy；immune function；inflammatory response 　　重型颅脑损伤多是由于外界因素导致头部损伤，与一般肢体损伤不同，颅脑损伤可导致患者神经系统出现