枯草杆菌二联活菌颗粒与熊去氧胆酸胶囊联合对新生儿黄疸指数及行为神经发育影响.docVIP

枯草杆菌二联活菌颗粒与熊去氧胆酸胶囊联合对新生儿黄疸指数及行为神经发育影响 　　[摘要]目的 探?枯草杆菌二联活菌颗粒与熊去氧胆酸胶囊联合对新生儿黄疸指数及行为神经发育的影响。方法 选择2015年1月～2016年1月我院收治的48例新生儿黄疸患儿，采用随机数字表法分为观察组和对照组，各24例。对照组单纯给予熊去氧胆酸胶囊治疗，观察组在此基础之上辅以枯草杆菌二联活菌颗粒进行治疗，比较两组临床效果，观察两组新生儿黄疸指数及行为神经发育情况。结果 观察组总有效率为95.83%，显著高于对照组的66.67%，差异有统计学意义（P0.05）。与治疗前比较，两组治疗后血清胆红素水平均显著下降（P0.01）；治疗后观察组血清胆红素水平显著低于对照组，差异有统计学意义（P0.01）。第2、3、4、5天比较观察组黄疸指数显著低于对照组，差异有统计学意义（P0.01），且两组黄疸指数水平均呈不断下降。与治疗前相比，两组治疗后NBNA评分均有显著下降（P0.01）；治疗后观察组NBNA评分显著低于对照组，差异有统计学意义（P0.01）。结论 枯草杆菌二联活菌颗粒与熊去氧胆酸胶囊联合治疗新生儿黄疸效果显著，可有效降低患儿的血清胆红素浓度和黄疸指数，同时对促进行为神经发育有重要意义，值得临床推广应用。 　　[关键词]枯草杆菌二联活菌颗粒；熊去氧胆酸胶囊；新生儿；黄疸指数；行为神经发育 　　[中图分类号] R722.17 [文献标识码] A [文章编号] 1674-4721（2016）11（a）-0089-03 　　[Abstract]Objective To investigate the effects of live combined Bacillus subtilis two bacteria particles and Ursodeoxycholic Acid Capules on neonatal jaundice index and behavior neural developme.Methods A total of 48 cases of neonates with jaundice in our hospital from January 2015 to January 2016 were divided into observation group （24 cases） and control group （24 cases） by random number table method，patients in the control group were given Ursodeoxycholic Acid Capsules treatment，patients in the observation group were given live combined Bacillus subtilis two bacteria particles treatment on the basis of control group.The neonatal jaundice index and behavior neural developme of two groups were observed.Results Total effective rate in the observation group was 95.83%，significantly higher than 66.67% in the control group （P0.05）.Serum bilirubin levels of two groups after treatment were decreased than that before treatment （P0.01）；serum bilirubin level in the observation group after treatment was significantly lower than that in the control group （P0.01）.The jaundice index of the observation group on the 2nd，3rd，4th and 5th day was significantly lower than that of the control group （P0.01），and the jaundice index level of two groups was decreased.The NBNA scores of two groups was significantly decreased （P0.01） after treat