母体环境暴露与胎儿先天性心脏病病因相关性研究.docVIP

母体环境暴露与胎儿先天性心脏病病因相关性研究 　　【摘要】目的：探讨母体环境暴露与胎儿先天性心脏病（congenital heart disease， CHD）病因的相关性， 对CHD的预防进行临床指导。方法：回顾性分析 2014.11～2017.11来我院就诊的62例先天性心脏病胎儿的母亲为观察组，同期出生的62例健康胎儿的母亲为对照组，通过本院自制的调查问卷，对两组胎儿的母亲家族史、生育年龄、民族、健康状况、孕产史、药物接触史、农药接触史、孕前及孕期环境嘈杂情况、孕期胎儿情况、教育情况、不良生活史、收入情况、工作情况等情况进行调查分析。结果：观察组女性胎儿比例显著高于对照组，差异有统计学意义，P0. 05 ；观察组母亲的先天性心脏病家族史、生育年龄、健康状况、流产史、药物接触史、农药接触史、噪声、不良妊娠史、胎儿异常、不良生活史、收入等因素与对照组相比，差异有统计学意义，P0. 05。结论：母体孕前期和孕期的多种环境因素与胎儿先天性性脏病的发生相关，改善母体的健康状况，减少危险因素的暴露，对防控胎儿先天性心脏病的发生具有重要意义。 　　【关键词】母体；环境因素；胎儿；先天性心脏病；相关性 　　Relationship between maternal environmental exposure and etiology of fetal congenital heart disease 　　Abstract Objective： To explore the relationship between maternal environmental exposure and the etiology of fetal congenital heart disease （CHD） and to provide clinical guidance for the prevention of CHD. Methods ： The mothers of 62 congenital heart disease fetuses who visited our hospital from 2014.11 to 2017.11 were retrospectively analyzed. The mothers of 62 healthy fetuses born in the same period were the control group， t hrough the self-made questionnaire in our hospital， we analyzed the mothers family history， birth age， ethnicity， health status， mothers history， drug exposure history， history of exposure to pesticides， noisy environment before and during pregnancy， fetus during pregnancy， education situation ， Bad life history， income， work conditions and other circumstances for investigation and analysis. Results： The proportion of female fetuses in observation group was significantly higher than that in control group， the difference was statistically significant （P 0.05）； compared with the control group， the factors such as family history of congenital heart disease， childbearing age， health status， abortion history， drug exposure history， history of pesticide exposure， noise， adverse pregnancy history， fetal abnormalities， adverse life history， The difference was statistically significant， P 0.05. Conclusion： The maternal preconception and pregnancy multi