液基薄层细胞学检测在宫颈癌筛查中意义.docVIP

液基薄层细胞学检测在宫颈癌筛查中意义 　　[摘要] 目的 探析液基薄层细胞学检测在宫颈癌筛查中的价值。 方法 整群选取该院妇科门诊筛查宫颈癌的989例患者，均采取TCT检测，对于结果异阳性的87例患者进一步给予HPV及宫颈病理学检查，分析检查结果。结果 TCT检测阳性者87例，其中ASC-US 35例，LSIL 32例，ASC-H 5例，HSIL15例，与病理诊断符合率是40.0%、68.75%、80.0%、86.67%，各组间符合率比较差异有统计学意义（χ2=12.058，P0.05）；HPV检测结果显示，在炎症、CIN I、II、III阳性率呈升高的趋势，比较差异有统计学意义（P0.05）。 结论 在宫颈癌筛查中，采取TCT检查能够早期发现异常，可作为首选方式，在此基础上联合宫颈活检及HPV检测，能够进一步进行确诊，值得应用。 　　[关键词] TCT；HPV；宫颈活检；宫颈癌 　　[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-0742（2016）03（b）-0189-02 　　[Abstract] Objective To discuss the value of liquid-based cytology test in the screening of cervical cancer. Methods 989 cases of patients with cervical cancer screened by the gynecologic clinic of our hospital were selected and detected by TCT， 87 cases of patients with positive were given further HPV test and cervical biopsy， and the were analyzed. Results 87 cases was positive by TCT detection， among them， ASC-US was in 35 cases， LSIL was in 32 cases， ASC-H was in 5 cases and HSIL was in 15 cases， the coincidence rates of pathologic diagnosis were respectively 40.0%， 68.75%，8 0.0% and 86.67%， and there were differences in the coincidence rate between groups by comparison （χ2=12.058， P0.05）， the HPV test showed that the positive rates of inflammation， CIN I，II and III presented an increasing trend， and there were differences by comparison（P0.05）. Conclusion TCT can early find abnormity in the screening of cervical cancer and can be used as the preferred way， and the abnormity can be further diagnosed by TCT combined with cervical biopsy and HPV test， which is worth application. 　　[Key words] TCT； HPV； Cervical biopsy； Cervical cancer 　　宫颈癌是临床上比较常见的恶性肿瘤，从癌前病变至宫颈癌是一个较为漫长的过程。研究报道，HPV感染是引起宫颈癌的主要高危因素。TCT检测的基础上联合HPV及宫颈病例活检，显著提高了宫颈癌检出率，三者具有互补作用，这对于早期诊断具有重要的临床意义[1]。该研究整群选择2013年1月―2015年2月门诊筛查宫颈癌的989例患者，采取TCT检查，结果呈阳性者87例，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　整群选取2013年1月―2015年2月该院妇科门诊筛查宫颈癌的989例患者，均采取TCT检测，结果异阳性者87例，其中年龄22～58岁，平均（39.6±5.8）岁，检查前48 h无性生活，无阴道冲洗及用药情况，无宫颈手术史。 　　1.2 方法 　　1.2.1 TCT检查 所有患者均进行TCT检查，将引导分泌物擦拭后。使用