甘精胰岛素沙格列汀联合用药对2型糖尿病患者血糖控制作用观察.docVIP

甘精胰岛素沙格列汀联合用药对2型糖尿病患者血糖控制作用观察 　　【摘要】 目的：探?甘精胰岛素+沙格列汀联合用药对2型糖尿病患者血糖的控制作用。方法：选取本院收治的102例2型糖尿病患者作为研究对象，采用随机数字表法分为试验组和对照组，每组51例。试验组患者给予甘精胰岛素联合沙格列汀治疗，对照组患者给予甘精胰岛素联合阿卡波糖治疗，观察两组患者治疗后空腹血糖、糖化血红蛋白、胰岛素用量以及不良反应发生情况。结果：试验组患者和对照组患者治疗后空腹血糖分别为（6.34±0.55）mmol/L和（6.97±0.86）mmol/L，试验组患者显著低于对照组（P0.05）。结论：甘精胰岛素联合沙格列汀治疗2型糖尿病，可显著降低空腹血糖和糖化血红蛋白，有效控制血糖水平，值得临床推广。 　　【关键词】 2型糖尿病； 甘精胰岛素； 沙格列汀； 血糖控制 　　Effects of Glargine Combined with Saxagliptin on Blood Glucose Control of Type 2 Diabetic Patient/SU Guo-tao.//Medical Innovation of China，2016，13（35）：039-042 　　【Abstract】 Objective：To evaluate the effect of Glargine combined with Saxagliptin on blood glucose control of type 2 diabetic patient.Method：A total of 102 type 2 diabetic patients were divided into the control group and the experimental group according to the random number table method.Each group included 51 patients.The experimental group was treated by Glargine combined with Saxagliptin，while the control group was treated by Glargine combined with Acarbose.The fasting blood glucose，glycated hemoglobin，insulin dosage and adverse reaction after treatment of two groups were observed.Result：The fasting blood glucose of the experimental group and the control group were（6.34±0.55）mmol/L and（6.97±0.86）mmol/L，the experimental group was significantly lower than that of the control group（P0.05）.Conclusion：Glargine combined with Saxagliptin treated with type 2 diabetic patients can significantly reduce the fasting blood glucose and glycated hemoglobin，control the patients’ blood glucose levels effectively.It is worthy of promotion. 　　【Key words】 Type 2 diabetic； Glargine； Saxagliptin； Blood glucose control 　　First-author’s address：Xiamen Chang Gung Hospital，Xiamen 350200，China 　　doi：10.3969/j.issn.1674-4985.2016.35.010 　　2型糖尿病，又称成人发病型糖尿病，高发于40岁以上人群[1]。相比于1型糖尿病，2型糖尿病患者体内胰岛细胞具有产生胰岛素的功能，患者血糖偏高的原因在于，患者体内胰岛素的作用效果较差[2-3]。因此，2型糖尿病的治疗可通过口服降糖药物刺激机体分泌胰岛素，或者增强机体对于胰岛素的敏感性[4]，但随着疾病的发展，2型糖尿病患者仍需注射胰岛素治疗[5]。2型糖尿病的治疗关键在于，如何控制患者血糖的波动。近年来，二肽基肽酶-4抑制剂越来越受到关注，其