生长抑素联合奥美拉唑治疗肝硬化食管静脉曲张破裂出血临床研究.docVIP

生长抑素联合奥美拉唑治疗肝硬化食管静脉曲张破裂出血临床研究 　　【中图分类号】R575.2 【文献标识码】A 【文章编号】1672－3783(2011)11－0085－01 　　 　　【摘要】目的 观察生长抑素联合奥美拉唑治疗肝硬化食管静脉曲张破裂出血的临床疗效和安全性。方法 88例肝硬化食管静脉曲张破裂出血患者随机分为观察组和对照组。两组均采取常规治疗，观察组在此基础上加用生长抑素联合奥美拉唑，对照组采用奥美拉唑联合垂体后叶素，比较两组临床疗效、止血时间、止血率和不良反应。结果 观察组总有效率为90.91%；对照组总有效率为70.45%，观察组疗效优于对照组(P0.05)；观察组止血时间、止血率优于对照组(P0.05)；观察组不良反应少于对照组。结论 生长抑素联合奥美拉唑疗效确切，不良反应少，值得临床推广应用。 　　【关键词】生长抑素；奥美拉唑；肝硬化食管静脉曲张 　　The clinical observation of Sandostatin combined with Omeprazole on treating variceal bleeding of esophagus with liver cirrhosisPeng yan 　　【Abstract】Objective To observe the clinical effect of Sandostatin combined with Omeprazole on treating variceal bleeding of esophagus with liver cirrhosis.Methods 88 cases of variceal bleeding of esophagus with liver cirrhosis were randoms divided into observation group and control group.Two groups were given conventional treatment,the patients with observation group were given Sandostatin combined with Omeprazole, while the patients with control groups were given pituitrin combined with Omeprazole,the curative effect, the average peroid of hemostasis, hemostasis rate and adverse reaction of two groups were compared after the treatment.Results The observation group got the effective rate 90.91%,while the control group was 70.45%,there was significant difference between the two group(P0.05);the haemostasis effective rate and haemostasis time of the observation group are significantly superior to the control group(P0.05); ADR in the observation group was less than that in the control group.Conclusion Sandostatin combined with Omeprazole has obvious effect on Cirrhosis esophageal varices,its worthy of clinic application. 　　【Key words】Sandostatin;Omeprazole; Cirrhosis esophageal varices 　　 　　食管胃底静脉曲张是由于长期门脉高压的结果。由于本病缺少可长期持续有??地控制门脉高压的治疗方法，因此，对于因肝硬化所导致的食管胃底静脉曲张的破裂出血就成了肝硬化患者走向不治的主要原因之一［1］。生长抑素能有效地降低内脏血管的血流量和降低门脉压力，减少食管胃底曲张静脉的压力，从而减少食管胃底静脉曲张导致的出血，并能促进止血，近年来广泛应用于临床。我院采用人工合成的环状十四肽生长抑素(思他宁)结合奥美拉唑治疗肝硬化食管静脉曲张破裂出血，取得满意的疗效，现报告如下。 　　1 资料与方法 　　1.1 一般