溃疡性结肠炎患者TNFα表达及三七抗复发研究.docVIP

溃疡性结肠炎患者TNFα表达及三七抗复发研究 　　[摘要] 目的：探讨溃疡性结肠炎（UC）缓解期血清TNF-α水平与复发的相关性及三七预防复发的作用。方法：选取我院UC缓解期患者60例，检测其血清TNF-α值，并以30例健康受试者为正常对照。60例患者随机分为试验组和对照组，每组各30例。对照组采用柳氮磺胺嘧啶治疗，试验组联合中药三七治疗，3个月后统计复发情况。结果：试验组与对照组的血清TNF-α值分别为（18.5±9.6） pg/ml和（8.8±5.3） pg/ml，两组比较差异有高度统计学意义（P0.01）；TNF-α高表达组与低表达组的复发率分别为35.29 %和11.54 %（P0.05）；TNF-α水平复发组与未复发组分别为（26.3±8.7） pg/ml和（14.7±7.4） pg/ml（P0.05）；试验组与对照组复发率分别为13.33 %和36.67 %，两组比较差异有统计学意义（P0.05）。结论：缓解期UC患者的血清TNF-α水平与其后一定时间内的复发率呈正相关，可作为UC缓解期的监测指标，中药三七具有预防UC复发的作用。 　　[关键词] 溃疡性结肠炎缓解期；TNF-α；复发；中药三七 　　[中图分类号] R289.5 [文献标识码]A [文章编号]1673-7210（2011）04（a）-099-02 　　 　　Correlation of the TNF-α levels and the clinical observation on Panax Notoginseng of anti-relapse in the treatment of patients with ulcerative colitis 　　MA Puwei, CHEN Jinquan, PENG Lin, LIN Xifen, DU Gangyi 　　Traditional Chinese Medicine Hospital of Zhongshan City, Guangdong Province, Zhongshan 528401, China 　　[Abstract] Objective: To observe the correlation of TNF-α levels in remission and the preventive effect of Panax Notoginseng on reactivation in patients with ulcerative colitis. Methods: TNF-a levels in plasma were detected in 60 patients who with ulcerative colitis in remission, and 30 normal persons were collected as control group. These patients were randomly classified into treatment group (n=30) and control group (n=30). Relapse rate was inspected after 3 months treatment. Results: The TNF-α levels in treatment group were significantly higher than those of control group [(18.5±9.6) pg/ml and (8.8±5.3) pg/ml] (P0.01), the relapse rate of high expression of TNF-α was higher than that of low expression of TNF-α（35.29% and 11.54%）（P0.05），the relapse rate in treatment group was obviously lower than that in control group（13.33% and 36.67%）(P0.05). Conclusion: The relapse rate of ulcerative colitis is correlated to the TNF-α levels. Panax Notoginseng can reduce the occurrence of Ulcerative Colitis. 　　[Key words] Ulcerative colitis in Remission; Tumor necrosis factor-alpha; Recurrence; P