清肺利气通络颗粒对肺炎支原体肺炎儿童血清IL―23IL―17水平影响.docVIP

清肺利气通络颗粒对肺炎支原体肺炎儿童血清IL―23IL―17水平影响 　　摘要：目的探讨清肺利气通络颗粒对肺炎支原体肺炎（MPP）儿童血清白介素23（IL-23）、白介素17（IL-17）水平的影响。方法将60例符合纳入标准的MPP儿童随机分为对照组（n=30）和治疗组（n=30）。其中，对照组采用阿奇霉素（75mg?kg-1）和氨溴索注射液（15mg?d-1）静脉输液治疗；治疗组在对照组的基础上加用清肺利气通络颗粒口服治疗；疗程均为7 d。在治疗前后分别采集患儿血清标本，采用相关ELISA试剂盒检测各组IL-23和IL-17水平。结果治疗组30例，痊愈24例，显效3例，有效3例；对照组30例，治愈17例，显效10例，有效1例，无效2例；治疗组临床疗效显著优于对照组（P005）。2组治疗后证候积分均较治疗前积分显著减少（P均005）；治疗组治疗后积分较对照组显著减少（P005）。2组治疗后血清IL-23水平均较治疗前明显降低（P均005）；治疗组治疗后血清IL-23水平较对照组显著降低（P005）。2组治疗后血清IL-17水平均较治疗前明显降低（P均005）；治疗组治疗后血清IL-17水平较对照组显著降低（P005）。结论清肺利气通络颗粒联合常规治疗儿童MPP疗效显著优于常规治疗，加用清肺利气通络颗粒治疗，并可下调血清IL-23及IL-17水平，值得进一步深入研究。 　　关键词：清肺利?馔?络；肺炎支原体肺炎；白介素23；白介素17 　　中图分类号：R5631文献标志码：A文章编号：1007-2349（2017）07-0016-05 　　【Abstract】Objective： To study the effect of Qingfei Liqi Tongluo Granule on serum interleukin-23 （IL-23） and interleukin-17 （IL-17） in children with mycoplasma pneumoniae （MPP） Methods： 60 MPP children were randomly divided into a control group （n=30） and a treatment group （n=30） The control group was given intravenous infusion of azithromycin （75mg?kg-1） and ambroxol injection （15mg?d-1） while the treatment group was given oral medication of Qingfei Liqi Tongluo Granule on the basis of western medicine of the control group 7 days was a course of treatment The serum samples of the child patients were collected before and after treatment and the levels of their IL-23 and IL-17 were detected by ELISA kit Results： Among 30 child patients in the treatment group， 24 cases were cured， 3 markedly effective， other 3 effective and 0 cases ineffective Among 30 child patients in the control group， 17 cases were cured， 10 cases markedly effective， 1 case effective and 2 cases ineffective The clinical effect of the treatment group was better than that of the control group （P005） The scores of the two groups significantly decreased when compared with those of prior treatment （P005）， but the score of the treatment group was much lower that of the control group after the treatment （P005） The level of serum IL-