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溶媒及配制后存放时间对注射用双黄连类过敏反应影响
溶媒及配制后存放时间对注射用双黄连类过敏反应影响
[摘要]选择正确的溶媒和配制后现用现配是合理用药的基础,也是最直接有效的提高中药注射剂安全性的途径。在该研究中,借助小鼠类过敏反应模型,将注射用双黄连分别用0.9%氯化钠注射液和5%葡萄糖注射液配制相应浓度,与血管通透性增高指示剂伊文思蓝溶液混合后一次性静脉注射入小鼠体内,观察比较给药后30 min小鼠耳廓血管通透性增高情况;另外将注射用双黄连配制后放置10 min,2.5,6,20 h,运用与前相同的检测方法对不同放置时间的注射用双黄连进行类过敏反应检测。结果显示注射用双黄连分别用0.9%氯化钠注射液和5%葡萄糖注射液配制后,相同剂量情况下其诱发的小鼠类过敏反应没有显著差异,但是配制后随着时间的延长,注射用双黄连诱发的小鼠类过敏反应有加重趋势。
[关键词]配制溶媒;配制时间;类过敏反应;血管通透性;小鼠;注射用双黄连
Influence of solvent and drug preparation time on Shuanghuanglian
injections induce pseudo-allergic reaction
YI Yan1, LIANG Ai-hua1*, LI Chun-ying1, ZHANG Yu-shi1, ZHAO Yong1, HAN Jia-yin1, LU Yu-ting1,2
(1.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Key laboratory of
Beijing for Identification and Safety of Chinese Medicine, Beijing 100700, China;
2.Capital Medical University, Beijing 100069, China)
[Abstract]Choosing the right solvent and timely use is the basis of rational drug use and the most direct and efficient way to improve the safety of traditional Chinese medicine injections. This study aimed to evaluate the influence of solvent and drug preparation time on Shuanghuanglian injection inducing pseudo-allergic reactions with mouse mode. The two tests were carried out:①Comparative experiment between different solvent: Shuanghuanglian injection preparation to the appropriate concentration with 0.9% sodium chloride injection and 5% dextrose injection, mixed with Evans blue, at one time intravenous injected into mice, 30 minutes later, the mouse ears vascular permeability were observed and compared. ②Comparative experiment among different preparation time: placed 10 min, 2.5 h, 6 h and 24 h after Shuanghuanglian injection were prepared and then to detect the pseudo-allergic reactions in mice using the same methods as in ①. The results showed that there was no significant difference in the pseudo-allergic reactions in mice which induced by the same dose of Shuanghuanglian injection, respectively with 0.9% sodium chlor
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