男性吸烟与骨密度及骨生化指标关系调查与分析.docVIP

男性吸烟与骨密度及骨生化指标关系调查与分析 　　摘 要：目的 研究男性吸烟与骨密度及骨生化指标关系的调查与分析。方法 选择2012年1月～2016年1月某社区的500例吸烟男性为观察组，另外选择500例不吸烟的男性作为对照组，比较两组研究对象的骨代谢及骨生化指标，分析吸烟对上述两种因素造成的影响。结果 观察组各部位骨密度均显著低于对照组（P0.05），观察组sBAP和年龄明显高于对照组（P0.05），但25-羟基总维生素D则显著低于对照组（P0.05），差异有统计学意义。结论 男性随着年龄的增长骨量会逐渐丢失，而吸烟会造成男性骨生化指标和骨转换水平升高，加速骨量的丢失，所以吸烟是造成骨质疏松的危险因素之一，要预防骨质疏松的发生应当提倡戒烟。 　　关键词：男性；吸烟；骨密度；骨生化指标 　　中图分类号：R580 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.01.041 　　文章编号：1006-1959（2018）01-0110-02 　　Investigation and Analysis of the Relationship between Male Smoking and Bone Mineral Density and Bone Biochemical Index 　　HUANG Qiong-e，XU Ying-bo 　　（Department of Endocrinology，Qujing First Peoples Hospital，Qujing 655000，Yunnan，China） 　　Abstract：Objective To investigate the relationship between male smoking and bone mineral density and bone biochemical markers.Methods 500 smokers from January 2012 to January 2016 in a community were selected as the observation group.Another 500 non-smokers were selected as the control group.The bone metabolism and bone biochemical indexes of the two groups were compared，analysis of the impact of smoking on these two factors.Results The observation group BMD were significantly lower than the control group（P0.05），the observation group sBAP and age was significantly higher than the control group（P0.05），but the total 25- hydroxy vitamin D was significantly lower than the control group（P0.05），the difference was statistically significant.Conclusion With the increase of bone age of the male will gradually lost， and smoking will result in increased male bone biochemical markers and bone turnover level，accelerated loss of bone mass， so smoking is one of the risk factors causing osteoporosis，to prevent osteoporosis should give up smoking. 　　Key words：Male；Smoking；Bone density；Bone biochemical index 　　骨质疏松症（osteoporosis，OP）是一种严重影响患者生存质量的增龄性疾病，是目前最常见的一种代谢性骨疾病，患者主要以骨量减少、骨组织微结构退化、骨脆性增加而导致骨折[1-2]。现阶段对于绝经妇女骨转换的研究较多，而对于男性的骨丢失、骨转换指标的研究则较少。本次研究对某社区的500例吸??男性的骨代谢、股生化指标的转化进行了研究，并对500例不吸烟的男性作为对比，现报道如下。 　　1