男性性功能症状评分联合游离睾酮水平诊断迟发性性腺功能减退症临床研究.docVIP

男性性功能症状评分联合游离睾酮水平诊断迟发性性腺功能减退症临床研究 　　【摘要】目的：探讨分析男性性功能症状评分联合游离睾酮水平诊断迟发性性腺功能减退症患者的有效性和可行性。方法：选择对象为2010年3月至2014年3月期间来我院体检的100例中老年人，对其进行自制男性性功能症状评分问卷、中老年男子雄激素缺乏问卷、老年男子症状问卷，同时检测血清中游离睾酮水平，观察分析男性性功能症状评分与游离睾酮水平诊断迟发性性腺功能减退症的临床效果。结果：男性性功能症状评分问卷筛选LOH的阳性率为280%；中老年男子雄激素缺乏问卷筛选LOH的阳性率为730%；老年男子症状问卷筛选LOH阳性率为610%；游离睾酮水平在阳性人群和阴性人群存在显著性差异（P005）。结论：男性性功能症状评分联合游离睾酮水平能够更准确地预测诊断迟发性性腺功能减退症，是一种值得在临床上推广的诊断方法。 　　【关键词】男性性功能症状评分；游离睾酮水平；迟发性性腺功能减退症；诊断 　　【Abstract】Objectives： To investigate the effectiveness and feasibility of male sexual function symptom score joint free testosterone levels on diagnosis of delayed hypogonadism. Methods： 100 elderly persons received physical examination in our hospital from March 2010 to March 2014 were selected. The homemade male sexual function symptom score questionnaire， the androgen deficiency questionnaire for elderly men and older men symptom questionnaire were conducted. Meanwhile， serum free testosterone levels were tested to observe and analyze clinical effects of male sexual function score and free testosterone levels on the diagnosis of delayed hypogonadism. Results： In male sexual function symptom score questionnaire screening， LOH positive rate was 28.0%； in androgen deficiency screening questionnaire in elderly men， the LOH positive was 73.0%； in older men symptom questionnaire screening， LOH positive rate was 61.0%； free testosterone levels in the positive crowd and negative crowd were significantly different （P005）. Conclusion： Male sexual function symptom score joint free testosterone levels can more accurately predict the diagnosis of late-onset hypogonadism， which is worthy of promotion. 　　【Key words】Male sexual function symptom score； Free-testosterone levels； Late-onset hypogonadism； Diagnosis 　　【中图分类号】R167【文献标志码】A 　　随着全球人口老龄化的加剧，老年人的身心健康越来越受到全社会的关注，并且关于老年疾病的研究也越来越广泛。男性迟发性性腺功能减退（LOH）是一种与男性年龄老化密切相关的临床和生化的综合征，是临床上常见的内分泌疾病[1]。该疾病最明显的特征是血清睾酮的下降[2]。男性在30岁以后，血清中睾酮水平随年龄增长呈逐步降低趋势；在大于65岁或70岁的老年男性中，游离睾酮的降低更加明显[3]。LOH的常见临床特征是肌肉强度和力量的下降、骨质疏松、向心性肥胖、