白三烯受体拮抗剂在哮喘患者中抗炎改善免疫功能效果分析.docVIP

白三烯受体拮抗剂在哮喘患者中抗炎改善免疫功能效果分析 　　【摘要】 目的 探?白三烯受体拮抗剂（孟鲁司特）在哮喘患者中抗炎以及改善免疫功能的效果。方法 80例哮喘患者， 随机分为对照组（30例）和观察组（50例）。对照组患者采用糖皮质激素治疗， 观察组在对照组基础上给予孟鲁司特治疗， 比较两组患者治疗前后的炎性因子水平及免疫功能指标。 　　结果 治疗前两组患者的C反应蛋白（CRP）、白细胞介素-6（IL-6）水平比较差异均无统计学意义（P0.05）。治疗后观察组CRP、IL-6水平为（6.32±2.22）mg/L、（67.43±12.29）ng/L， 对照组为（10.20±3.06）mg/L、（89.02± 　　15.47）ng/L；治疗后两组患者的CRP、IL-6水平均低于治疗前， 且观察组低于对照组， 差异有统计学意义（P0.05）；治疗后两组患者CD8+低于治疗前， CD4+高于治疗前， 且观察组CD8+低于对照组， CD4+高于对照组， 差异均有统计学意义（P0.05）。两组均未见明显不良反应。结论 孟鲁司特能够提高哮喘的治疗效果， 其作用机制可能与其降低患者的炎性因子水平以及提高免疫功能有关。 　　【关键词】 白三烯受体拮抗剂；哮喘；抗炎；免疫功能 　　DOI：10.14163/j.cnki.11-5547/r.2017.34.051 　　Effect of leukotriene receptor antagonist on anti-inflammation and improving immune function in asthmatic patients QIU Xu-ke， YUE Tie-gang， CHEN Yu-guang， et al. Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University， Shenzhen 518104， China 　　【Abstract】 Objective To discuss the effect of leukotriene receptor antagonist （Montelukast） on anti-inflammation and improving immune function in asthmatic patients. Methods A total of 80 asthmatic patients were randomly divided into control group （30 cases） and observation group （50 cases）. The control group was treated with glucocorticoids， and the observation group was treated with Montelukast on the basis of the control group. Comparison were made on levels of inflammatory factors and immune function indexes before and after treatment in two groups. Results Before treatment， both groups had no statistically significant difference in levels of C reactive protein （CRP） and interleukin -6 （IL-6） （P0.05）. After treatment， the observation group had CRP and IL-6 level as （6.32±2.22） mg/L and （67.43±12.29） ng/L， which were （10.20±3.06） mg/L and （89.02±15.47） ng/L in the control group. After treatment， both groups had lower CRP and IL-6 level than before treatment， and the observation group was lower than the control group. Their difference was statistically significant （P0.05）. After treatment， both groups had lower CD8+ than before tre