男性阻塞性睡眠呼吸暂停综合症患者血清性激素水平研究.docVIP

男性阻塞性睡眠呼吸暂停综合症患者血清性激素水平研究 　　【摘要】目的：探讨分析男性阻塞性睡眠呼吸暂停综合症患者体内性激素分泌水平及与其疾病的相关性，为临床疾病诊治提供一定理论依据。方法：研究对象为2012年2月到2014年2月我院收治的、经临床检查确诊为男性阻塞性睡眠呼吸暂停综合症患者共94例作为观察组，同时选取同期在我院就诊的健康男性患者94例作为对照组。对所有研究对象进行动态整夜睡眠监测及性激素水平的测定，此外通过Pearson相关性分析研究其性激素水平与阻塞性睡眠呼吸暂停综合症的相关性。结果：观察组体重指数及腹围明显高于对照组，经统计学分析P005。观察组AHI、平均血氧明显低于对照组，差异显著，P005。对照组最低血氧及氧降指数明显高于观察组，经统计学分析，P005。观察组血清中睾酮、催乳素及黄体生成素分泌水平均明显低于对照组，经统计学分析，P005。睾酮水平与BMI、胸围、腹围及病程成负相关，与年龄成正相关。结论：男性阻塞性睡眠呼吸暂停综合症患者性激素的分泌水平与健康男性之间存在差异，但其分泌与OSAHS相关指标无相关性而与BMI有显著相关性。 　　【关键词】睡眠呼吸暂停综合症；性激素；相关性分析 　　Sex hormone changes and sexual dysfunction in male patients with obstructive sleep apneahypopnea syndromeDU Junwei1， LU Zhouyu2， QIAN Yingjun2， CHEN Min3. 1. Department of Respiration， Fuyang City Peoples Hospital， Hangzhou 311400，Zhejiang， China； 2. Department of Urology， Fuyang City Peoples Hospital， Hangzhou 311400， Zhejiang， China； 3. Pharmacy Department， Huzhou First Peoples Hospital， Huzhou 313000， Zhejiang， China 　　【Abstract】Objectives： To explore the sex hormone changes and sexual dysfunction in male patients with obstructive sleep apneahypopnea syndrome so as to provide certain theoretical basis for clinical diagnosis and treatment. Methods： 94 male patients with obstructive sleep apneahypopnea syndrome treated in our hospital from February 2012 to February 2014 were selected as observation group， and at the same time， 94 health males were selected as the control group. All the objects of study were under dynamic monitoring sleep all night and determination of sex hormone levels. Through Pearson correlation analysis， we studied the correlation between sex hormone levels and obstructive sleep apneahypopnea syndrome. Results： The body mass index （BMI） and abdominal girth in observation group was obviously higher than these of control group， P 　　【Key words】Obstructive sleep apneahypopnea syndrome； Sex hormone； Relationship analysis 　　【中图分类号】R167【文献标志码】A 　　阻塞性睡眠呼吸暂停综合症（obstructive sleep apneahypopnea syndrome，OSAHS）是一种常见的呼吸系统疾病，其定义为成人于7h的夜间睡眠时间内，至少有