萆Z研究进展.docVIP

萆Z研究进展 　　[摘要]萆?Z为《中国药典》中粉萆?Z和绵萆?Z，具有利湿去浊、祛风除痹的功效。临床上主要用于膏淋、关节不利和风湿痹痛等的治疗，疗效显著，应用前景广阔。然而由于萆?Z来源混杂，品种混乱以及缺少相关质量评价，使其近年来研究进展缓慢。以往对萆?Z的研究主要体现在化学成分上，其主要含有甾体类、二芳基庚烷类和木脂素类等多种化学成分，其中甾体皂苷类成分是其主要成分也是其发挥药理活性的主要物质。近年来研究发现萆?Z及其主要成分在降尿酸，抗炎镇痛，抗骨质疏松等方面作用显著，并取得了较大的进展，为临床药物的研究和开发提供了实验性依据。但其发挥药理作用的具体物质和具体机制尚不清晰，有待进一步的探索。笔者通过查阅国内外相关文献，从萆?Z的化学成分、质量评价和药理作用等方面对其进行了全面综述，以期为萆?Z的进一步研究、开发和应用提供参考。 　　[关键词]萆?Z； 化学成分； 质量评价； 药理作用 　　Research progress of Bixie 　　CHEN Chong， ZENG Chenhong， ZHANG Siqi， WEI Li* 　　（Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China） 　　[Abstract]The Dioscorea hypoglauca rhizome and D spongiosa rhizome in China Pharmacopoeia are often used as Bixie in clinically， with the function of removing dampness， clearing away turbidness and dispelling wind to remove pain， and has been widely used in stranguria marked by chyluria， joint stiffness and rheumatic arthralgia It has obvious curative effect and broad application prospect However， in recent years the progress of research is slow for its miscellaneous sources， chaotic varieties and lack of relevant quality assessment The previous research on Bixie is mainly reflected in the chemical compositions， mainly including steroids， diarylheptanoids and lignans and so on Among them， steroidal saponins are the main components and the main effective substances for their pharmacological activities Recent studies have shown that Bixie and its main components have significant effects in antitrioxypurine， antiinflammation， analgesia and antiosteoporosis， and have made great progress， providing an experimental basis for the research and development of clinical drugs But the specific substance and specific mechanism of its pharmacological action are not clear， and need further exploration By consulting the relevant literature at home and abroad， the author has summarized the chemical constituents， quality evaluation， pharmacological action of Bixie， hoping to provide a reference for further research， developme