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斑蝥酸钠维生素b6注射液联合同期放化疗治疗局部晚期鼻咽癌的临床观察-中西医结合临床专业论文
PAGE
PAGE VI
Abstract
Objective
The clinical randomized controlled trial was undertaken to evaluate the efficacy and side effects of sodium cantharidate and vitamin B6 injection combined with concurrent chemo-radiotherapy for locally advanced nasopharyngeal carcinoma(LA-NPC).
Methods
According to the inclusion and exclusion criteria, patients with LA-NPC undergoing chemo-radiotherapy who were charged in the First Affiliated Hospital of Jinan University between May and November 2013 were selected as participants of this study. 49 patients with LA-NPC were randomized into two groups: 24 cases in observation group were treated sodium cantharidate and vitamin B6 injection combined with concurrent chemo-radiotherapy(CCRT), whereas 25 cases in control group received CCRT. The patients routine blood test, liver and kidney function and MRI examination of nasopharynx and neck to assess the efficacy and safety of sodium cantharidate and vitamin B6 injection combined with CCRT for LA-NPC. At the end of all treatment, two groups of patients’ TCM clinical symptoms, functional status and acute toxicity during treatment were observed and compared. Statistic analysis were performed with SPSS 13.0. Statistical methods included statistical
description, t-test, χ2 test, rank sum test and repeated measurement ANOVA.
Results
The comparison of general information of patients with LA-NPC showed that the differences among both groups were insignificant statistically(P0.05). The two groups were well-balanced and comparable.
The reduction of leukocyte count in observation group was lower than in control
group(F = 4.01 , P = 0.004 < 0.05). The inhibition of erythrocyte count and
hemoglobin in observation group was less severe than in control group, so did the recovery(the values of F were respectively 3.55 and 6.47, the values of P were respectively 0.015 and 0.000), whereas it didn’t consider that the changes of liver and
kidney function in both groups were different statis
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