美沙拉嗪对溃疡性结肠炎患者肠道黏膜屏障功能和免疫功能系统评价.docVIP

美沙拉嗪对溃疡性结肠炎患者肠道黏膜屏障功能和免疫功能系统评价 　　[摘要] 目的 探?美沙拉嗪应用于溃疡性结肠炎对患者肠道黏膜屏障功能与免疫功能的影响。 方法 选取2016年 3月～2017年2月在我院接受治疗的溃疡性结肠炎患者93例，按照用药不同，分成美沙拉嗪组（n=47）和柳氮磺吡啶组（n=46），于用药前和用药1疗程、2疗程后，比较两组免疫功能、肠道黏膜屏障功能变化及肠黏膜恢复情况。结果 用药前，两组IgA、IgG、IgM、Fas/FasL及CD4+、CD8+和CD4+/CD8+差异均不显著（P0.05），用药1疗程、2疗程后，两组各项指标均显著变化，且用药1疗程后的各项指标与2疗程后均有显著差异（P0.05），用药1疗程、2疗程后，两组各项肠道黏膜屏障功能表达水平均显著降低，且用药1疗程与用药2疗程各项指标间有显著差异（P0.05），用药1疗程、2疗程后，两组临床症状总积分均显著下降，美沙拉嗪组显著低于柳氮磺吡啶组（P0.05）。 结论 对于溃疡性结肠炎患者，可采取美沙拉嗪进行治疗，能够有效促进肠黏膜恢复，其作用机制可能和改善肠道黏膜屏障功能与调节免疫功能有关。 　　[关键词] 美沙拉嗪；溃疡性结肠炎；肠道黏膜屏障功能；免疫功能 　　[中图分类号] R574.62 [文献标识码] B [文章编号] 1673-9701（2018）09-0035-04 　　Systematic review of mesalazine on intestinal mucosal barrier and immune function in patients with ulcerative colitis 　　MA Yan 　　Department of Gastroenterology， Second Hospital of Chaoyang City in Liaoning Province，Chaoyang 122000，China 　　[Abstract] Objective To investigate the effect of mesalazine on intestinal mucosal barrier function and immune function in patients with ulcerative colitis. Methods A total of 93 patients with ulcerative colitis who were treated in our hospital from March 2016 to February 2017 were selected and divided into mesalazine group（n=47） and sulfasalazine group（n=46） according to different drugs. The changes of immune function， intestinal mucosal barrier function and intestinal mucosal recovery were compared before medication and after 1 course and 2 courses of treatment. Results Before treatment， there was no significant difference in IgA， IgG， IgM， Fas/FasL， CD4+， CD8+ and CD4+/CD8 between the two groups（P0.05）. There was a significant difference in indexes between groups after 1 course and 2 courses of treatment， and there was a significant difference between the indexes after 1 course of treatment and those after 2 courses of treatment（P0.05）. The expression levels of intestinal mucosal barrier function in two groups were significantly lower after 1 course and 2 courses of medication. There was significant difference in between indicators after1 cou