美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎疗效分析.docVIP

美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎疗效分析 　　[摘要] 目的 研究美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的治疗效果。 方法 选取136例溃疡性结肠炎患者，按照随机数字表法分成观察组和对照组，每组68例，对照组采用美沙拉嗪治疗，观察组患者采用美沙拉嗪联合双歧杆菌三联活菌治疗。对比两组患者治疗前后的血清炎性因子、肠炎活?又甘?评分、内镜评分、治疗效果等。 结果 观察组患者治疗总有效率94.12%，明显高于对照组的72.06%，差异有统计学意义（P0.05）；两组患者经过治疗后，血清炎性因子、肠炎活动指数、内镜评分均有显著改善（P0.05），而观察组改善更加显著，与对照组治疗后相比，差异有统计学意义（P0.05）。 结论 美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的疗效显著，明显改善患者血清炎性因子水平，值得在临床上推广应用。 　　[关键词] 美沙拉嗪；双歧杆菌三联活菌；血清炎性因子；肠炎活动指数评分 　　[中图分类号] R574.62 [文献标识码] B [文章编号] 1673-9701（2017）31-0043-03 　　[Abstract] Objective To study the therapeutic effect of mesalazine combined with bifidobacterium tripleviable bacteriaon ulcerative colitis. Methods 136 patients with ulcerative colitis were divided into observation group（n=68） and control group（n=68） according to the random number table method. The control group was treated with mesalazine. The patients in the observation group were treated with mesalazine combined with bifidobacterium triple viable bacteria.The serum inflammatory factors， enteritis activity index score， endoscopic score， treatment effect between the two groups before and after treatment were compared. Results The total effective rate of the observation group was 94.12%， which was significantly higher than that of the control group（72.06%）， and the difference was statistically significant（P0.05）. The serum inflammatory factors， enteritis activity index， endoscopy score in the two groups were significantly improved after treatment（P0.05）. While the improvement of the observation group was more significant than that of the control group after treatment， and the difference was statistically significant（P0.05）. Conclusion Mesalazine combined with bifidobacterium triple viable bacteria has a significant effect in the treatment of ulcerative colitis， which significantly improves the level of serum inflammatory factors in patients and is worthy of clinical application. 　　[Key words] Mesalazine； Bifidobacterium triple viable bacteria； Serum inflammatory factor； Enteritis activity in