老年女性2型糖尿病患者下肢血管病变与血清同型半胱氨酸关系研究.docVIP

老年女性2型糖尿病患者下肢血管病变与血清同型半胱氨酸关系研究 　　[摘要] 目的 研究老年女性2型糖尿病患者下肢血管病变与其血清中同型半胱氨酸（Hcy）水平的关系。 方法 选择2010年1月～2012年12月于广东省惠州市中心人民医院内分泌科住院的老年女性2型糖尿病患者100例为A组；体检中心健康老年女性60例为B组。用彩色多普勒检查下肢血管情况，并测定血糖、血脂、血清Hcy水平、糖化血红蛋白（HbA1c）等指标，了解血清Hcy水平与糖尿病下肢血管病变间的关系。 结果 A组中有下肢血管病变亚组患者血清Hcy水平明显高于无下肢血管病变亚组患者[（18.23 ± 4.61）μmol/L比（12.13 ± 2.50）μmol/L]及B组（18.23 ± 4.61）μmol/L比（11.09 ± 2.25）μmol/L]，差异均有高度统计学意义（均P 0.05）。 结论 血清Hcy水平升高与老年女性2型糖尿病下肢血管病变有关。 　　[关键词] 2型糖尿病；下肢血管病变；同型半胱氨酸 　　[中图分类号] R543.5 [文献标识码] A [文章编号] 1673-7210（2013）11（a）-0071-03 　　Research of relationship between the serum homocysteine level and peripheral artery diseases in old female with type 2 diabetes mellitus 　　XIANG Wei HUANG Xiaomin HE Ruowen 　　Department of Endocrinology， the Central Peoples Hospital of Huizhou City， Guangdong Province， Huizhou 516001， China 　　[Abstract] Objective To research the relationship between the serum homocysteine（Hcy）level and peripheral artery diseases in old female with type 2 diabetes mellitus. Methods 100 old females with type 2 diabetes mellitus treated in the Central Peoples Hospital of Huizhou City from January 2010 to December 2012 were selected as group A； 60 healthy old females from physical examination center of this hospital were selected as group B. The peripheral artery color Doppler sonography and the level of plasma glucose， plasma lipids， serum Hcy and glycosylated hemoglobin（HbA1c） of the two groups were investigated and compared. Results The serum Hcy level of those patients with peripheral artery disease in group A were found to be obvious higher than those patients without peripheral artery disease in group A [（18.23 ± 4.61） μmol/L vs （ 12.13 ± 2.50） μmol/L] and those healthy females in group B [（18.23 ± 4.61） μmol/L vs （11.09 ± 2.25） μmol/L]， the differences were statistically significant（all P 0.05）. Conclusion The elevation of serum Hcy level has relation with the peripheral artery disease in old females with type 2 diabetes mellitus. 　　[Key words] Type 2 diabetes mellitus；