老年呼吸道感染应用高剂量左氧氟沙星注射液治疗可行性研究.docVIP

老年呼吸道感染应用高剂量左氧氟沙星注射液治疗可行性研究 　　[摘要] 目的 分析老年呼吸道感染应用高剂量左氧氟沙星注射液治疗的可行性。方法 方便选取2015年6月―2017年1月84例老年呼吸道感染患者，并随机分组。对照组42例采用头孢哌酮钠进行治疗，左氧氟沙星组42例应用高剂量左氧氟沙星注射液治疗。比较两组研究对象呼吸道感染治疗效果；呼吸道感染症状得到控制的时间、住院接受治疗的时间；干预前后患者白细胞水平、C反应蛋白水平、不良反应出现情况。结果 左氧氟沙星组研究对象呼吸道感染治疗效果95.24%，高于对照组80.95%（P0.05）；干预后左氧氟沙星组白细胞水平、C反应蛋白水平优于对照组（P0.05）。左氧氟沙星组仅有1例出现轻微腹泻，对照组有4例出现腹泻和3例恶心呕吐（P0.05）。结论 老年呼吸道感染应用高剂量左氧氟沙星注射液治疗的可行性高，具有较高的安全性，可快速控制感染，降低机体炎症水平，缩短治疗时间，值得推广应用。 　　[关键词] 老年呼吸道感染；高剂量；左氧氟沙星注射液；治疗可行性 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）08（a）-0124-03 　　[Abstracts] Objective This paper tries to analyze the feasibility of high-dose levofloxacin injection in elderly patients with respiratory tract infection. Methods A total of 84 elderly patients with respiratory tract infection were convenient selection in this study from June 2015 to January 2017 and were randomly grouped. 42 patients in the control group were treated with cefoperazone sodium and 42 patients in the levofloxacin group were treated with high-dose levofloxacin injection. The treatment effect of respiratory tract infection of the two groups， the time of control of respiratory tract infection， the time of hospitalization， the level of white blood cells and the level of C-reactive protein before and after intervention， and the occurrence of adverse reaction were compared. Results The curative effect of levofloxacin group on respiratory tract infection was 95.24%， higher than that of the control group of 80.95%（P0.05）； respiratory tract infection symptoms control time， hospital treatment time of the levofloxacin group was （4.12±0.12），（6.14±1.53） days， shorter than those of the control group of（6.24±1.21）（8.90±2.14） days，（P0.05）. The level of white blood cells and the level of C-reactive protein in levofloxacin group were better than those in the control group（P0.05）. Levofloxacin group showed only 1 case of mild diarrhea， the control group had 4 cases of diarrhea and 3 cases of nausea and vomiting（P0.05）. Conclusion The levofloxacin injection i