莫匹罗星对血透患者中心静脉置管感染预防及治疗作用.docVIP

莫匹罗星对血透患者中心静脉置管感染预防及治疗作用 　　[摘要] 目的 探讨莫匹罗星对血透患者中心静脉置管感染的预防及治疗作用。 方法 选取114例2013年7月～2014年7月期间来我院就诊并使用中心静脉导管治疗的血透患者，将所有患者分为两组。观察组57例，患者在血透治疗后，在常规换药后于中心静脉导管的出管口外用莫匹罗星治疗。对照组57例，使用常规换药方法治疗。对比两组患者的痊愈时间、感染发生率和治疗总有效率。 结果 观察组颈内静脉感染2例，感染率为3.5%，置管时间（22.42±5.22）d，股静脉感染3例，感染率5.3%，置管时间（19.16±3.13）d，锁骨下静脉感染2例，感染率3.5%，置管时间（29.23±4.92）d；对照组静脉感染6例，感染率为10.5%，置管时间（16.82±4.33）d，股静脉感染4例，感染率为7.0%，置管时间（15.26±3.88）d，锁骨下静脉感染4例，感染率7.0%，置管时间（19.65±4.68）d，差异有统计学意义（P0.05）。 结论 静脉置管的导管口处外涂莫匹罗星能有效地降低中心静脉导管相关感染率，使患者的导管留置时间延长，患者易于接受，且费用较低，操作简便，值得推广。 　　[关键词] 莫罗匹星；中心静脉导管；血液透析；感染 　　[中图分类号] R459.5 [文献标识码] B [文章编号] 1673-9701（2015）14-0067-04 　　[Abstract] Objective To analyze and discuss the prevention and treatment effect of mupirocin on infection for hemodialysis patients with central venous catheterization （CVC）. Methods A total of 114 cases hemodialysis patients receiving CVC in our hospital from July 2013 to July 2014 were randomly divided into two groups. 57 patients in the observation group were given externally mupirocin at the outlet of central venous catheter in addition to conventional medicine. 57 cases in the control group were given only conventional medicine. Healing time， incidence of infection and the total treatment efficiency of the two groups were compared. Results In the observation group， there were 2 cases of internal jugular vein infection with an infection rate of 3.5% and the average catheterization time was （22.42±5.22）d. And there were a total of 3 cases of femoral vein infection with an infection rate of 5.3% and the catheterization time was （19.16±3.13）d. Also there were 2 cases of subclavian vein infection with an infection rate of 3.5% and the catheterization time was （29.23±4.92）d； In the control group， there were a total of 6 cases of intravenous infection with an infection rate of 10.5% and the catheterization time was （16.82±4.33）d. And there were 4 cases of femoral vein infection with an infection rate of 7.0% and the catheterization time was （15.26±3.88）d. Also there