舒筋活血汤治疗慢性创伤性膝关节滑膜炎临床疗效及对肿瘤坏死因子―α白细胞介素―1β影响观察.docVIP

舒筋活血汤治疗慢性创伤性膝关节滑膜炎临床疗效及对肿瘤坏死因子―α白细胞介素―1β影响观察 　　【摘要】 目的 探?舒筋活血汤治疗慢性创伤性膝关节滑膜炎的临床疗效及对肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）的影响。方法 76例慢性创伤性膝关节滑膜炎患者作为研究对象， 将其按照临床治疗方法的不同分为对照组与实验组， 每组38例。对照组患者采用滑膜炎颗粒进行治疗， 实验组患者采用舒筋活血汤进行治疗。比较两组治疗前后TNF-α、IL-1β水平及临床治疗效果。结果 治疗前， 两组患者TNF-α和IL-1β水平比较差异均无统计学意义（P0.05）；治疗 　　4周后， 实验组患者TNF-α和IL-1β水平（7.46±2.13）、（6.23±1.74）ng/L明显优于对照组（13.46±3.42）、（10.42±2.36）ng/L， 差异均具有统计学意义（P0.05）。实验组临床治疗总有效率92.11%明显高于对照组73.68%， 差异具有统计学意义（P0.05）。结论 舒筋活血汤用于慢性创伤性膝关节滑膜炎的治疗效果显著， 能有效降低TNF-α和IL-1β水平， 具有强筋健骨以及消肿止痛等疗效， 值得临床推广应用。 　　【关键词】 舒筋活血汤；膝关节滑膜炎；肿瘤坏死因子-α；白细胞介素-1β；临床疗效 　　DOI：10.14163/j.cnki.11-5547/r.2017.34.058 　　Observation on clinical efficacy of Shujin Huoxue decoction on chronic traumatic knee synovitis and its effect on tumor necrosis factor-α and interleukin-1β LI Jian， ZHANG Jin-feng， XING Zhen-long. Guangdong Integrated Traditional Chinese and Western Medicine Hospital， Foshan 528200， China 　　【Abstract】 Objective To discuss the clinical efficacy of Shujin Huoxue decoction on chronic traumatic knee synovitis and its effect on tumor necrosis factor-α （TNF-α） and interleukin-1β （IL-1β）. Methods A total of 76 chronic traumatic knee synovitis patients as study subjects were divided by different clinical treatment methods into control group and experimental group， with 38 cases in each group. The control group was treated with synovitis granule， and the experimental group was treated with Shujin Huoxue decoction. Comparison were made on TNF-α， IL-1β level before and after treatment and clinical treatment effect between two groups. Results Before treatment， both groups had no statistically significant difference in TNF-α and IL-1β level （P0.05）. After 4 weeks of treatment， the experimental group had obviously better TNF-α and IL-1β level as （7.46±2.13） and （6.23±1.74） ng/L than （13.46±3.42） and （10.42±2.36） ng/L in the control group， and their difference was statistically significant （P0.05）. The experimental group had obviously higher clinical total effective rate as 9