脂肪肝患者丙氨酸转氨酶异常与代谢综合征相关性研究.docVIP

脂肪肝患者丙氨酸转氨酶异常与代谢综合征相关性研究 　　摘 要 目的：探讨脂肪肝患者丙氨酸转氨酶（ALT）异常与代谢综合征（MS）之间的相关性。方法：自2015年1月―12月参加本院健康中心体检人员（n=52 092）中，抽取腹部B超提示脂肪肝并接受全套检查者（n=6 508）的体检结果，其中ALT指标异常者806例纳入病例组，ALT指标正常者5 702例纳入对照组。回顾性分析比较两组体格检查、ALT、FPG、血脂全套、SUA、腹部超声等。结果：病例组的BMI、TC、FPG、SUA、SBP水平均高于对照组（P0.05），而年龄、HDL-C水平低于对照组（P0.05）。结论：BMI、FPG、血脂、SBP、SUA水平均是脂肪肝患者ALT异常的危险因素。 　　关键词 脂肪性肝病 丙氨酸转氨酶 代谢综合征 　　中图分类号：R589； R575.5 文献标识码：A 文章编号：1006-1533（2016）11-0044-03 　　Study on the relationship between elevated ALT and metabolic syndrome in the patients with fatty liver disease * 　　HAN Hui**， GAO Yan， QUE Ting*** 　　（Department of Internal Medicine， Shanghai Postal and Telecommunication Hospital， Shanghai 200040， China） 　　ABSTRACT Objective： To study the relationship between elevated alanine aminiotransferase （ALT） and metabolic syndrome in the patients with fatty liver disease. Methods： The physical examination results from 6 508 cases with fatty liver prompted by an abdominal B ultrasound examination and receiving a full set of examination were extracted， in which 806 cases with ALT abnormality and the other 5 702 cases with ALT normality were divided into a case group and a control group， respectively. The data including physical examination， ALT， FPG， serum lipid-profile， SUA and ultrasonographic examination of liver were retrospectively analyzed. Results： The levels of BMI， FPG， TC， SUA and SBP were significantly higher in the case group than in the control group （P0.05）. However， the HDL-C level and age were significantly lower in the case group （P0.05）. Conclusion： The levels of BMI， FPG， TC， SUA and SBP are risk factors of ALT abnormality for patients with fatty liver disease. 　　KEY WORDS fatty liver disease； ALT； metabolic syndrome 　　作为重要的慢性非传染性疾病，脂肪性肝病现已取代病毒性肝炎，成为全球第一大肝病，对人类健康和社会发展构成严重威胁。丙氨酸转氨酶（alanine aminotransferase，ALT）异常是反映肝细胞损害的肝酶指标之一，监测肝酶、控制肝酶指标对于脂肪肝患者意义重大，影响疾病转归和预后。大多数学者已经将非酒精性脂肪性肝病（nonalcoholic fatty liver disease，NAFLD）作为代谢综合征（metabolic syndrome，MS）的组分之一，或MS在肝脏的表现[1]。本研究旨在探讨脂肪肝患者ALT异常与代谢综合征之间的相关